ADRA2C - adrenoceptor alpha 2C Gene

中文名称：肾上腺素受体α2C

种属: Homo sapiens

同用名: ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR

基因 ID: 152 | 基因类型: protein coding

关于 ADRA2C

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:3,766,385-3,768,526 (from NCBI)

This gene has 2 transcripts (splice variants), 228 orthologues, 18 paralogues and is associated with 1 phenotype.

功能概要

α-2-肾上腺素能受体是 G 蛋白偶联受体超家族的成员。它们包括 3 个高度同源的亚型：alpha2A、alpha2B 和 alpha2C。这些受体在调节交感神经和中枢神经系统肾上腺素能神经元释放神经递质方面起着关键作用。小鼠研究表明，alpha2A 和 alpha2C 亚型对于从心脏交感神经和中枢去甲肾上腺素能神经元释放递质的正常突触前控制是必需的。 alpha2A 亚型在高刺激频率下抑制递质释放，而 alpha2C 亚型在较低水平的神经活动下调节神经传递。该基因编码 alpha2C 亚型，其编码序列或非翻译序列均不含内含子。[RefSeq 提供，2008 年 7 月]

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

ADRA2C 基因产物(1)

mRNA	Protein	Name
NM_000683.4	NP_000674.2	alpha-2C adrenergic receptor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables alpha-2A adrenergic receptor binding	IPI IPI: 通过物理相互作用推断	16605244	GOA
enables alpha2-adrenergic receptor activity	EXP EXP: 通过实验结果推断	10948191	GOA
enables alpha2-adrenergic receptor activity	IDA IDA: 通过直接分析推断	17215105	GOA
enables epinephrine binding	IDA IDA: 通过直接分析推断	17215105	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16531006	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	16605244	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	16605244	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	17215105	GOA
involved in activation of protein kinase B activity	IDA IDA: 通过直接分析推断	17215105	GOA
involved in adrenergic receptor signaling pathway	IDA IDA: 通过直接分析推断	17215105	GOA
involved in positive regulation of MAPK cascade	IDA IDA: 通过直接分析推断	17215105	GOA
involved in positive regulation of neuron differentiation	IDA IDA: 通过直接分析推断	17215105	GOA
involved in receptor transactivation	IDA IDA: 通过直接分析推断	17215105	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	16605244	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	16605244	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADRA2C 蛋白结构

7tm_1

0
100
200
300
400
462 a.a.

蛋白主名

其他名称

alpha-2C adrenergic receptor

adrenergic, alpha-2C-, receptor

ADRA2C 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ADRA2C	P18825	P4HA3	Homo sapiens	Q7Z4N8	Validated Y2H	32296183
种属内	ADRA2C	P18825	CNPY2	Homo sapiens	Q9Y2B0	Validated Y2H	32296183
种属内	ADRA2C	P18825	CCDC24	Homo sapiens	Q8N4L8	Validated Y2H	32296183
种属内	ADRA2C	P18825	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
种属内	ADRA2C	P18825	CHCHD2	Homo sapiens	Q9Y6H1	Validated Y2H	32296183
种属内	ADRA2C	P18825	MKRN3	Homo sapiens	Q13064	Validated Y2H	32296183
种属内	ADRA2C	P18825	KLHL38	Homo sapiens	Q2WGJ6	Validated Y2H	32296183
种属内	ADRA2C	P18825	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
种属内	ADRA2C	P18825	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
种属内	ADRA2C	P18825	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Raynaud Disease

Raynaud'S Disease	Raynaud Phenomenon
Raynaud'S Syndrome	Raynaud'S
Cold Fingers, Hereditary	Raynaud'S Phenomenon
Raynaud'S Disease/Phenomenon	Raynauds Syndrome
Raynauds Phenomenon	Secondary Raynaud'S Phenomenon
Raynaud Syndrome

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Type 1 Diabetes Mellitus 22

Diabetes Mellitus, Insulin-Dependent, 22	IDDM22
T1D22	Insulin-Dependent Diabetes Mellitus 22
Diabetes Mellitus, Insulin-Dependent, Type 22

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Horner'S Syndrome

Horner Syndrome	Bernard-Horner Syndrome
Oculosympathetic Palsy	Bernard Horner Syndrome
Cervical Sympathetic Paralysis	Von Passow Syndrome
Cervical Sympathetic Dystrophy

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00413	ADRA2C Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ADRA2C	MGD	MGI:87936
Macaca mulatta	ADRA2C	VGNC	VGNC:69727
Rattus norvegicus	ADRA2C	RGD	RGD:2058
Felis catus	ADRA2C	VGNC	VGNC:59657
Bos taurus	ADRA2C	VGNC	VGNC:106633

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