2. Gene
  3. SH3D19 - SH3 domain containing 19 Gene

SH3D19 - SH3 domain containing 19 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 SH3 域 19

种属: Homo sapiens

同用名: EBP; EVE1; Kryn; Eve-1; SH3P19

基因 ID: 152503 | 基因类型: protein coding

关于 SH3D19

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:151,120,281-151,325,605 (from NCBI)

This gene has 14 transcripts (splice variants), 261 orthologues and 12 paralogues. Ubiquitous expression in fat (RPKM 43.0), gall bladder (RPKM 40.6) and 23 other tissues.

功能概要

该基因编码一个包含多个 SH3 结构域的蛋白质，该蛋白质通过 SH3 结构域与其他蛋白质 (如 EBP 和 ADAM 家族成员) 相互作用。该蛋白可能参与抑制 Ras 诱导的细胞转化和 Ras 介导的 EBP 对 ELK1 的激活，以及在 EGFR 配体脱落信号中调节 ADAM 蛋白。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a multiple SH3 domain-containing protein, which interacts with Other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

SH3D19 基因产物(14)

mRNA Protein Name
NM_001009555.4 NP_001009555.3 SH3 domain-containing protein 19 isoform 1
NM_001128923.2 NP_001122395.1 SH3 domain-containing protein 19 isoform 2
NM_001128924.2 NP_001122396.1 SH3 domain-containing protein 19 isoform 3
NM_001243349.2 NP_001230278.1 SH3 domain-containing protein 19 isoform 2
NM_001378121.1 NP_001365050.1 SH3 domain-containing protein 19 isoform 4
NM_001378122.1 NP_001365051.1 SH3 domain-containing protein 19 isoform 5
NM_001378123.1 NP_001365052.1 SH3 domain-containing protein 19 isoform 6
NM_001378124.1 NP_001365053.1 SH3 domain-containing protein 19 isoform 7
NM_001378126.1 NP_001365055.1 SH3 domain-containing protein 19 isoform 1
NM_001378127.1 NP_001365056.1 SH3 domain-containing protein 19 isoform 1
NM_001378128.1 NP_001365057.1 SH3 domain-containing protein 19 isoform 2
NM_001378129.1 NP_001365058.1 SH3 domain-containing protein 19 isoform 2
NM_001378130.1 NP_001365059.1 SH3 domain-containing protein 19 isoform 2
NM_001378131.1 NP_001365060.1 SH3 domain-containing protein 19 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables proline-rich region binding IPI
IPI: 通过物理相互作用推断
15280379 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15280379 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytoskeleton organization IMP
IMP: 通过突变表型推断
21834987 GOA
involved in positive regulation of membrane protein ectodomain proteolysis IMP
IMP: 通过突变表型推断
15280379 GOA
involved in regulation of cell morphogenesis IMP
IMP: 通过突变表型推断
21834987 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
15280379 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SH3D19 蛋白结构

SH3_2

SH3_2: Variant SH3 domain (419 - 470)

SH3_1

SH3_1: SH3 domain (501 - 546)

SH3_9

SH3_9: Variant SH3 domain (578 - 626)

SH3_1

SH3_1: SH3 domain (668 - 712)

SH3_9

SH3_9: Variant SH3 domain (737 - 785)

  • 0
  • 200
  • 400
  • 600
  • 790 a.a.
蛋白主名 其他名称

SH3 domain-containing protein 19

ADAM-binding protein Eve-1

SH3D19 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SH3D19 Q5HYK7 SH3YL1 Homo sapiens Q96HL8
Validated Y2H
25416956
种属内
SH3D19 Q5HYK7 SH3YL1 Homo sapiens Q96HL8
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Optic Atrophy 2

OPA2

Optic Atrophy, X-Linked

Optic Atrophy, Non-Leber Type, With Early Onset

Optic Atrophy 2, X-Linked

X-Linked Optic Atrophy 2

Early-Onset X-Linked Optic Atrophy

Non-Leber Type Optic Atrophy With Early-Onset

Optic Atrophy Type 2

Atrophy, Optic, Type 2
Chronic Intestinal Vascular Insufficiency

Chronic Mesenteric Ischemia

Cmi - Chronic Mesenteric Ischaemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12834 SH3D19 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SH3D19 MGD MGI:1350923
Canis familiaris SH3D19 VGNC VGNC:46122
Bos taurus SH3D19 VGNC VGNC:34570
Felis catus SH3D19 VGNC VGNC:65105
Rattus norvegicus SH3D19 RGD RGD:1304885
Macaca mulatta SH3D19 VGNC VGNC:77351
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