1. Gene
  2. SH3YL1 - SH3 and SYLF domain containing 1 Gene

SH3YL1 - SH3 and SYLF domain containing 1 Gene

中文名称:含 SH3 和 SYLF 域 1

种属: Homo sapiens

同用名: RAY

基因 ID: 26751 | 基因类型: protein coding

关于 SH3YL1

Cytogenetic location: 2p25.3 Genomic coordinates (GRCh38): 2:218,136-264,824 (from NCBI)

This gene has 29 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in kidney (RPKM 16.8), thyroid (RPKM 9.9) and 24 other tissues.

功能概要

启用磷酸酶结合活性和磷脂酰肌醇结合活性。预计在磷脂酰肌醇生物合成过程的上游或内部起作用,并调节荷叶边组装。位于荷叶边膜中。 [由基因组资源联盟提供,2022 年 4 月]

Enables Phosphatase binding activity and phosphatidylinositol binding activity. Predicted to act upstream of or within phosphatidylinositol biosynthetic process and regulation of ruffle assembly. Located in ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022]

SH3YL1 基因产物(4)

mRNA Protein Name
NM_001159597.3 NP_001153069.1 SH3 domain-containing YSC84-like protein 1 isoform 2
NM_001282682.2 NP_001269611.1 SH3 domain-containing YSC84-like protein 1 isoform 3
NM_001282687.2 NP_001269616.1 SH3 domain-containing YSC84-like protein 1 isoform 4
NM_015677.4 NP_056492.2 SH3 domain-containing YSC84-like protein 1 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatase binding IDA
IDA: 通过直接分析推断
21624956 GOA
enables phosphatidylinositol binding IDA
IDA: 通过直接分析推断
21624956 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in ruffle membrane IDA
IDA: 通过直接分析推断
21624956 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SH3YL1 蛋白结构

Ysc84

Ysc84: Las17-binding protein actin regulator (86 - 209)

SH3_9

SH3_9: Variant SH3 domain (290 - 340)

  • 0
  • 100
  • 200
  • 300
  • 342 a.a.
蛋白主名 其他名称

SH3 domain-containing YSC84-like protein 1

SH3 domain containing, Ysc84-like 1

SH3YL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SH3YL1 Q96HL8 SH3D19 Homo sapiens Q5HYK7-2
Y2H Array
32296183
种属内
SH3YL1 Q96HL8 SH3D19 Homo sapiens Q5HYK7-2
Y2H Prey Pooling
32296183
种属内
SH3YL1 Q96HL8 SH3D19 Homo sapiens Q5HYK7-2
Anti Tag CoIP
28514442
种属内
SH3YL1 Q96HL8 SH3D19 Homo sapiens Q5HYK7
Y2H Array
25416956
种属内
SH3YL1 Q96HL8 SH3D19 Homo sapiens Q5HYK7
Anti Tag CoIP
33961781
种属内
SH3YL1 Q96HL8 VPS37B Homo sapiens Q9H9H4
Validated Y2H
32296183
种属内
SH3YL1 Q96HL8 VPS37B Homo sapiens Q9H9H4
Y2H Array
25416956
种属内
SH3YL1 Q96HL8 VPS37B Homo sapiens Q9H9H4
Y2H Array
32296183
种属内
SH3YL1 Q96HL8 VPS37B Homo sapiens Q9H9H4
Y2H
21516116
种属内
SH3YL1 Q96HL8 VPS37B Homo sapiens Q9H9H4
Y2H Prey Pooling
32296183
种属内
SH3YL1 Q96HL8 ZBTB7B Homo sapiens O15156
Validated Y2H
25416956
种属内
SH3YL1 Q96HL8 ZBTB7B Homo sapiens O15156
Y2H Array
25416956
种属内
SH3YL1 Q96HL8 ZBTB7B Homo sapiens O15156
Y2H Prey Pooling
25416956
种属内
SH3YL1 Q96HL8 GFAP Homo sapiens P14136
Y2H Prey Pooling
25416956
种属内
SH3YL1 Q96HL8 GFAP Homo sapiens P14136
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Meier-Gorlin Syndrome 4

MGORS4

Meier-Gorlin Syndrome, Type 4

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SH3YL1 VGNC VGNC:77338
Felis catus SH3YL1 VGNC VGNC:65117
Mus musculus SH3YL1 MGD MGI:1346118
Rattus norvegicus SH3YL1 RGD RGD:1306440
Canis familiaris SH3YL1 VGNC VGNC:46137
Bos taurus SH3YL1 VGNC VGNC:34584