DAB2IP - DAB2 interacting protein Gene

中文名称：DAB2 相互作用蛋白

种属: Homo sapiens

同用名: AIP1; AIP-1; AF9Q34; DIP1/2

基因 ID: 153090 | 基因类型: protein coding

关于 DAB2IP

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:121,567,074-121,785,530 (from NCBI)

This gene has 11 transcripts (splice variants), 238 orthologues and 10 paralogues. Ubiquitous expression in colon (RPKM 8.5), testis (RPKM 8.5) and 24 other tissues.

功能概要

DAB2IP 是一种 Ras (MIM 190020) GTP 酶激活蛋白 (GAP) ，可作为肿瘤抑制因子。 DAB2IP 基因在前列腺癌和乳腺癌中被甲基化失活 (Yano 等人，2005 [PubMed 15386433]) 。[OMIM 提供，2010 年 5 月]

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]

DAB2IP 基因产物(3)

mRNA	Protein	Name
NM_001395010.1	NP_001381939.1	disabled homolog 2-interacting protein isoform 3
NM_032552.4	NP_115941.2	disabled homolog 2-interacting protein isoform 1
NM_138709.2	NP_619723.1	disabled homolog 2-interacting protein isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 14-3-3 protein binding	IDA IDA: 通过直接分析推断	17389591	GOA
enables SH3 domain binding	IDA IDA: 通过直接分析推断	19033661	GOA
NOT enables Toll-like receptor 4 binding	IDA IDA: 通过直接分析推断	19948740	GOA
enables death receptor binding	IPI IPI: 通过物理相互作用推断	15310755	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	12813029	GOA
enables kinase binding	IPI IPI: 通过物理相互作用推断	17389591	GOA
enables mitogen-activated protein kinase kinase binding	IPI IPI: 通过物理相互作用推断	17389591	GOA
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: 通过物理相互作用推断	12813029	GOA
enables phosphatidylinositol 3-kinase binding	IDA IDA: 通过直接分析推断	19033661	GOA
enables phosphatidylinositol 3-kinase regulatory subunit binding	IDA IDA: 通过直接分析推断	19903888	GOA
enables phosphatidylinositol-3-phosphate binding	IDA IDA: 通过直接分析推断	19948740	GOA
enables phosphatidylinositol-4-phosphate binding	IDA IDA: 通过直接分析推断	19948740	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12813029	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	12813029	GOA
enables protein kinase binding	IDA IDA: 通过直接分析推断	18281285	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	20080667	GOA
enables protein phosphatase 2A binding	IDA IDA: 通过直接分析推断	20080667	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: 通过直接分析推断	19903888	GOA
enables protein-containing complex binding	IDA IDA: 通过直接分析推断	19903888	GOA
enables signaling adaptor activity	IDA IDA: 通过直接分析推断	19903888	GOA
enables vascular endothelial growth factor receptor 2 binding	IPI IPI: 通过物理相互作用推断	19033661	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to interleukin-1	IDA IDA: 通过直接分析推断	19948740	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: 通过直接分析推断	19948740	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: 通过直接分析推断	12813029	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IDA IDA: 通过直接分析推断	19033661	GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: 通过突变表型推断	19903888	GOA
involved in intracellular signal transduction	IMP IMP: 通过突变表型推断	20080667	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	20080667	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	19903888	GOA
involved in negative regulation of G0 to G1 transition	IDA IDA: 通过直接分析推断	19903888	GOA
involved in negative regulation of GTPase activity	IMP IMP: 通过突变表型推断	20154697	GOA
involved in negative regulation of MAP kinase activity	IDA IDA: 通过直接分析推断	12813029	GOA
involved in negative regulation of MAP kinase activity	IMP IMP: 通过突变表型推断	20154697	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	20154697	GOA
involved in negative regulation of angiogenesis	IDA IDA: 通过直接分析推断	19033661	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	15310755	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	20080667	GOA
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	19903888	GOA
involved in negative regulation of endothelial cell migration	IMP IMP: 通过突变表型推断	19033661	GOA
involved in negative regulation of epithelial cell migration	IMP IMP: 通过突变表型推断	20080667	GOA
involved in negative regulation of epithelial cell proliferation	IMP IMP: 通过突变表型推断	20154697	GOA
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: 通过直接分析推断	20154697	GOA
involved in negative regulation of epithelial to mesenchymal transition	IMP IMP: 通过突变表型推断	20080667	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: 通过直接分析推断	19903888	GOA
involved in negative regulation of protein catabolic process	IDA IDA: 通过直接分析推断	19903888	GOA
involved in negative regulation of protein serine/threonine kinase activity	IMP IMP: 通过突变表型推断	20154697	GOA
involved in negative regulation of toll-like receptor 4 signaling pathway	IDA IDA: 通过直接分析推断	19948740	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15310755	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	20154697	GOA
involved in negative regulation of vascular endothelial growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	19033661	GOA
involved in positive regulation of JNK cascade	IDA IDA: 通过直接分析推断	17389591	GOA
involved in positive regulation of JUN kinase activity	IDA IDA: 通过直接分析推断	12813029	GOA
involved in positive regulation of MAPK cascade	IDA IDA: 通过直接分析推断	19903888	GOA
involved in positive regulation of apoptotic process	IDA IDA: 通过直接分析推断	17389591	GOA
involved in positive regulation of apoptotic signaling pathway	IDA IDA: 通过直接分析推断	19903888	GOA
involved in positive regulation of proteasomal protein catabolic process	IMP IMP: 通过突变表型推断	20080667	GOA
involved in positive regulation of protein serine/threonine kinase activity	IMP IMP: 通过突变表型推断	20080667	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: 通过直接分析推断	18281285	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15310755	GOA
involved in protein catabolic process	IDA IDA: 通过直接分析推断	17389591	GOA
involved in regulation of cell cycle	IDA IDA: 通过直接分析推断	19903888	GOA
involved in regulation of protein-containing complex assembly	IDA IDA: 通过直接分析推断	19948740	GOA
involved in tube formation	IMP IMP: 通过突变表型推断	19033661	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of AIP1-IRE1 complex	IDA IDA: 通过直接分析推断	18281285	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	15310755	GOA
located in endocytic vesicle	IDA IDA: 通过直接分析推断	19948740	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	15310755	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DAB2IP 蛋白结构

RasGAP

DUF3498

0
200
400
600
800
1000
1189 a.a.

蛋白主名

其他名称

disabled homolog 2-interacting protein

ASK-interacting protein 1

DAB2IP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DAB2IP	Q5VWQ8	DAB2IP	Homo sapiens	Q5VWQ8	Anti Bait CoIP	12813029
种属内	DAB2IP	Q5VWQ8	GSK3B	Homo sapiens	P49841	Anti Bait CoIP	20080667
种属内	DAB2IP	Q5VWQ8	MAP3K5	Homo sapiens	Q99683	Y2H	12813029
种属内	DAB2IP	Q5VWQ8	MAP3K5	Homo sapiens	Q99683	Anti Bait CoIP	12813029
种属内	DAB2IP	Q5VWQ8	SMARCA2	Homo sapiens	P51531	Y2H Pooling	21653829
种属内	DAB2IP	Q5VWQ8	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	33961781
种属内	DAB2IP	Q5VWQ8	MAP3K5	Bos taurus	F1MXH6	Anti Bait CoIP	12813029

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Arteriosclerosis

Arteriosclerotic Vascular Disease

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Aortic Aneurysm, Familial Abdominal, 1

Abdominal Aortic Aneurysm	Aortic Aneurysm, Familial Abdominal 1
Aneurysm, Abdominal Aortic	AAA
Aortic Aneurysm, Abdominal	AAA1
Aortic Aneurysm, Familial Abdominal	Aortic Aneurysm Abdominal
Abdominal Aortic Aneurysms	Abdominal Aortic Aneurysm Without Mention Of Perforation Or Rupture
Abdomen Aneurysm	Abdominal Aorta Aneurysm
Aneurysm Of Abdominal Aorta	Aortic Abdomen Aneurysm
Aaa - [Abdominal Aortic Aneurysm]	Abdominal Aneurysm
Abdominal Aorta Aneurysm Rupture	Abdominal Aorta Aneurysm Ruptured
Abdominal Aortic Aneurysm Which Has Ruptured	Ruptured Aaa
Abdomen Aorta Aneurysm Ruptured	Abdomen Aorta Rupture
Abdomen Aortic Aneurysm Rupture	Abdomen Aneurysm Rupture
Abdomen Aortic Aneurysm Ruptured	Abdomen Aortic Rupture
Abdominal Aorta Rupture	Abdominal Aortic Rupture
Rupture Abdomen Aorta Aneurysm	Rupture Abdominal Aortic Aneurysm
Ruptured Abdomen Aneurysm	Ruptured Abdomen Aorta
Ruptured Abdomen Aortic	Ruptured Abdominal Aneurysm
Ruptured Abdominal Aorta	Ruptured Abdominal Aortic
Ruptured Aorta Abdominalis Aneurysm	False Abdomen Aorta Aneurysm Ruptured
False Abdominal Aortic Aneurysm Ruptured	False Abdominal Aorta Aneurysm Ruptured
False Abdomen Aortic Aneurysm Ruptured

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03512	DAB2IP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	DAB2IP	RGD	RGD:621686
Mus musculus	DAB2IP	MGD	MGI:1916851
Felis catus	DAB2IP	VGNC	VGNC:61330
Bos taurus	DAB2IP	VGNC	VGNC:27866
Canis familiaris	DAB2IP	VGNC	VGNC:39760
Macaca mulatta	DAB2IP	VGNC	VGNC:71642

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DAB2IP - DAB2 interacting protein Gene

关于 DAB2IP

功能概要

DAB2IP 基因产物(3)

DAB2IP 蛋白结构

DAB2IP 蛋白互作信息

关联疾病

直系同源

热门区域

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DAB2IP - DAB2 interacting protein Gene

关于 DAB2IP

功能概要

DAB2IP 基因产物(3)

DAB2IP 蛋白结构

DAB2IP 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z