Hmgcr - 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Gene

中文名称：3-羟基-3-甲基戊二酰辅酶 A 还原酶

种属: Mus musculus

同用名: Red; HMG-CoAR

关于 Hmgcr

功能概要

该基因编码的蛋白可启动羟甲基戊二酰辅酶 A 还原酶 (NADPH) 活性。参与淀粉样蛋白-β 清除的负调节；蛋白质分解代谢过程的负调节；和蛋白质分泌的负调节。作用于胆固醇生物合成过程的上游或内部； MAP 激酶活性的负调节；和视觉学习。预测位于内质网。预测在内质网膜和过氧化物酶体膜中有活性。以多种结构表示，包括 autopod；鳃弓;中枢神经系统;前肢芽；和神经节。该基因的人类直系同源物与多种疾病有关，包括哮喘；冠状动脉疾病（多发性）；失智;糖尿病（多发性）；和神经退行性疾病（多种）。与人 HMGCR（3-羟基-3-甲基戊二酰辅酶 A 还原酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in negative regulation of amyloid-beta clearance; negative regulation of protein catabolic process; and negative regulation of protein secretion. Acts upstream of or within Cholesterol biosynthetic process; negative regulation of MAP kinase activity; and visual learning. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Is expressed in several structures, including autopod; branchial arch; central nervous system; forelimb bud; and ganglia. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]