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  2. Htr3a - 5-hydroxytryptamine (serotonin) receptor 3A Gene

Htr3a - 5-hydroxytryptamine (serotonin) receptor 3A Gene

中文名称:5-羟色胺 (血清素) 受体 3A

种属: Mus musculus

同用名: 5-HT3; 5-HT3A; 5-HT3R

基因 ID: 15561 | 基因类型: protein coding

关于 Htr3a

Chromosome 9: 48,810,513-48,822,399 reverse strand.GRCm39:CM001002.3

This gene has 2 transcripts (splice variants), 215 orthologues, 41 paralogues and is associated with 27 phenotypes. Biased expression in colon adult (RPKM 3.9), adrenal adult (RPKM 3.2) and 14 other tissues.

功能概要

实现相同的蛋白质结合活性。预计参与多个过程,包括化学突触传递;离子跨膜转运蛋白活性的正向调节;和膜电位的调节。预计在离子传输的上游或内部起作用。预计位于多个细胞成分中,包括轴突;卵裂沟;和神经细胞体。预计是血清素激活的阳离子选择性通道复合物的一部分。预计在神经元投射和突触中活跃。预计是质膜的组成部分。以多种结构表达,包括中枢神经系统;眼睛;胆囊;泌尿生殖系统;和直觉。该基因的人类直系同源物与肠易激综合征有关。与人 HTR3A(5-羟色胺受体 3A)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables identical protein binding activity. Predicted to be involved in several processes, including chemical synaptic transmission; positive regulation of ion transmembrane transporter activity; and regulation of membrane potential. Predicted to act upstream of or within ion transport. Predicted to be located in several cellular components, including axon; cleavage furrow; and neuronal cell body. Predicted to be part of serotonin-activated cation-selective channel complex. Predicted to be active in neuron projection and synapse. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; eye; gallbladder; genitourinary system; and gut. Human ortholog(s) of this gene implicated in irritable bowel syndrome. Orthologous to human HTR3A (5-hydroxytryptamine receptor 3A). [provided by Alliance of Genome Resources, Apr 2022]

Htr3a 基因产物(2)

mRNA Protein Name
NM_001099644.1 NP_001093114.1 5-hydroxytryptamine receptor 3A isoform 2 precursor
NM_013561.2 NP_038589.2 5-hydroxytryptamine receptor 3A isoform 1 precursor

Htr3a 蛋白结构

LIC

LIC: TIGR00860 (4 - 476)

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  • 483 a.a.
蛋白主名 其他名称

5-hydroxytryptamine receptor 3A

5-hydroxytryptamine receptor 3

5HT3 serotonin receptor

serotonin receptor 3A

serotonin-gated ion channel receptor

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Htr3a NCBI NCBI:3359