2. Gene
  3. Htr6 - 5-hydroxytryptamine (serotonin) receptor 6 Gene

Htr6 - 5-hydroxytryptamine (serotonin) receptor 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：5-羟色胺 (血清素) 受体 6

种属: Mus musculus

同用名: 5-HT6

基因 ID: 15565 | 基因类型: protein coding

关于 Htr6

Chromosome 4: 138,788,419-138,802,881 reverse strand.GRCm39:CM000997.3

This gene has 2 transcripts (splice variants), 114 orthologues, 9 paralogues and is associated with 7 phenotypes. Biased expression in cortex adult (RPKM 1.8), frontal lobe adult (RPKM 1.5) and 11 other tissues.

功能概要

预计该基因编码的蛋白可启动 G 蛋白偶联血清素受体活性和神经递质受体活性。参与大脑皮层细胞迁移和 TOR 信号的正向调节。位于纤毛。表达于大脑皮层中间区；大脑皮层室下区；和皮质板。该基因的人类直系同源物与阿尔茨海默病有关。与人类 HTR6（5-羟色胺受体 6）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Involved in cerebral cortex cell migration and positive regulation of TOR signaling. Located in cilium. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; and cortical plate. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human HTR6 (5-hydroxytryptamine receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Htr6 基因产物(2)

mRNA Protein Name
NM_001377096.1 NP_001364025.1 5-hydroxytryptamine receptor 6
NM_021358.2 NP_067333.1 5-hydroxytryptamine receptor 6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled serotonin receptor activity IDA
IDA: 通过直接分析推断
11406289 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
23027611 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cerebral cortex cell migration IMP
IMP: 通过突变表型推断
25078650 MGI
involved in positive regulation of TOR signaling IDA
IDA: 通过直接分析推断
23027611 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cilium IDA
IDA: 通过直接分析推断
22179047 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Htr6 蛋白结构

7tmA_5-HT6

7tmA_5-HT6: cd15054 (28 - 53)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (28 - 332)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (60 - 86)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (98 - 128)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (140 - 163)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (184 - 213)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (262 - 292)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (300 - 325)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
蛋白主名 其他名称

5-hydroxytryptamine receptor 6

5-HT-6

serotonin receptor 6

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06480 HTR6 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06481 Htr6 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06482 Htr6 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Htr6 NCBI NCBI:3362
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