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  2. Htr7 - 5-hydroxytryptamine (serotonin) receptor 7 Gene

Htr7 - 5-hydroxytryptamine (serotonin) receptor 7 Gene

中文名称:5-羟色胺 (血清素) 受体 7

种属: Mus musculus

同用名: 5-HT7; 5-HT-X

基因 ID: 15566 | 基因类型: protein coding

关于 Htr7

Chromosome 19: 35,936,134-36,034,907 reverse strand.GRCm39:CM001012.3

This gene has 6 transcripts (splice variants), 221 orthologues, 9 paralogues and is associated with 12 phenotypes. Biased expression in CNS E18 (RPKM 2.3), cortex adult (RPKM 1.5) and 8 other tissues.

功能概要

预计该基因编码的蛋白可启动 G 蛋白偶联血清素受体活性和神经递质受体活性。预计参与G蛋白偶联受体信号通路,偶联环核苷酸第二信使和化学突触传递。预测作用于信号转导的上游或内部。预测位于质膜中。预计是膜的组成部分。预计在树突中活跃。预计是质膜的组成部分。以多种结构表达,包括脂肪组织;消化系统;脑;免疫系统;和生殖系统。该基因的人类直系同源物与酒精使用障碍有关。与人类 HTR7(5-羟色胺受体 7)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adipose tissue; alimentary system; brain; immune system; and reproductive system. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Htr7 基因产物(6)

mRNA Protein Name
NM_008315.3 NP_032341.2 5-hydroxytryptamine receptor 7 isoform 1
NM_001347442.2 NP_001334371.1 5-hydroxytryptamine receptor 7 isoform 2
NM_001360298.1 NP_001347227.1 5-hydroxytryptamine receptor 7 isoform 5 precursor
NM_001360297.1 NP_001347226.1 5-hydroxytryptamine receptor 7 isoform 4 precursor
NM_001360300.1 NP_001347229.1 5-hydroxytryptamine receptor 7 isoform 5 precursor
NM_001360318.1 NP_001347247.1 5-hydroxytryptamine receptor 7 isoform 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled serotonin receptor activity IDA
IDA: 通过直接分析推断
8394987 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Htr7 蛋白结构

7tmA_5-HT7

7tmA_5-HT7: cd15329 (99 - 397)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (118 - 144)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (157 - 187)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (199 - 221)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (238 - 267)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (322 - 352)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (365 - 390)

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  • 448 a.a.
蛋白主名 其他名称

5-hydroxytryptamine receptor 7

serotonin receptor 7

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Htr7 NCBI NCBI:3363