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  2. DAPK3 - death associated protein kinase 3 Gene

DAPK3 - death associated protein kinase 3 Gene

中文名称:死亡相关蛋白激酶 3

种属: Homo sapiens

同用名: DLK; ZIP; ZIPK

基因 ID: 1613 | 基因类型: protein coding

关于 DAPK3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,958,453-3,971,099 (from NCBI)

This gene has 7 transcripts (splice variants), 152 orthologues and 4 paralogues. Ubiquitous expression in endometrium (RPKM 16.5), prostate (RPKM 15.3) and 25 other tissues.

功能概要

死亡相关蛋白激酶 3 (DAPK3) 在哺乳动物细胞中过表达时会诱导细胞凋亡的形态学变化。这些结果表明 DAPK3 可能在诱导细胞凋亡中发挥作用。[RefSeq 提供,2008 年 7 月]

Death-associated protein kinase 3 (DAPK3) induces morphological changes in Apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of Apoptosis. [provided by RefSeq, Jul 2008]

DAPK3 基因产物(2)

mRNA Protein Name
NM_001348.3 NP_001339.1 death-associated protein kinase 3
NM_001375658.1 NP_001362587.1 death-associated protein kinase 3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
10356987 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18239682 GOA
enables leucine zipper domain binding IPI
IPI: 通过物理相互作用推断
10580117 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15292222 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
18239682 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
10356987 GOA
enables small GTPase binding IDA
IDA: 通过直接分析推断
23454120 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in apoptotic process IDA
IDA: 通过直接分析推断
10580117 GOA
involved in apoptotic process IMP
IMP: 通过突变表型推断
12917339 GOA
involved in cellular response to type II interferon IDA
IDA: 通过直接分析推断
18995835 GOA
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
10356987 GOA
involved in negative regulation of translation IDA
IDA: 通过直接分析推断
18995835 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
21487036 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
21454679 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
18239682 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
10356987 GOA
involved in regulation of actin cytoskeleton organization IDA
IDA: 通过直接分析推断
23454120 GOA
involved in regulation of focal adhesion assembly IDA
IDA: 通过直接分析推断
23454120 GOA
involved in regulation of mitotic cell cycle IMP
IMP: 通过突变表型推断
21487036 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DAPK3 蛋白结构

Pkinase

Pkinase: Protein kinase domain (13 - 275)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
蛋白主名 其他名称

death-associated protein kinase 3

DAP kinase 3

DAPK3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DAPK3 O43293 LUZP1 Homo sapiens Q86V48
Pull Down
32707033
种属内
DAPK3 O43293 LUZP1 Homo sapiens Q86V48
Anti Tag CoIP
35271311
种属内
DAPK3 O43293 PPP1R12A Homo sapiens O14974
Anti Tag CoIP
15292222
种属内
DAPK3 O43293 PPP1R12A Homo sapiens O14974
Pull Down
15292222
种属内
DAPK3 O43293 NLK Homo sapiens Q9UBE8
Anti Bait CoIP
21454679
种属内
DAPK3 O43293 DAPK3 Homo sapiens O43293
X-Ray Diffraction
18239682
种属内
DAPK3 O43293 DAPK3 Homo sapiens O43293
Solution Sedimentation
18239682
种属内
DAPK3 O43293 CEP170 Homo sapiens Q5SW79
Pull Down
32707033
种属内
DAPK3 O43293 DAPK3 Homo sapiens O43293
Anti Tag CoIP
21487036
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 DAPK3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77286 DAPK3/ZIPK Protein, Human (sf9, GST) O43293-1 (M1-R454) ≥95%

DAPK3 抗体

目录号 产品名 应用 反应物种
HY-P83574 DAP kinase 3 Antibody (YA3319) WB Human

直系同源

种属 基因名 来源 基因 ID
Felis catus DAPK3 VGNC VGNC:61338
Bos taurus DAPK3 VGNC VGNC:27878
Mus musculus DAPK3 MGD MGI:1203520
Macaca mulatta DAPK3 VGNC VGNC:71734
Rattus norvegicus DAPK3 RGD RGD:621766
Canis familiaris DAPK3 VGNC VGNC:39771
Others DAPK3 NCBI