PPP1R12A - protein phosphatase 1 regulatory subunit 12A Gene

中文名称：蛋白磷酸酶 1 调节亚基 12A

种属: Homo sapiens

同用名: MBS; GUBS; M130; MYPT1

基因 ID: 4659 | 基因类型: protein coding

关于 PPP1R12A

Cytogenetic location: 12q21.2-q21.31 Genomic coordinates (GRCh38): 12:79,773,563-79,935,460 (from NCBI)

This gene has 23 transcripts (splice variants), 205 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in endometrium (RPKM 18.7), esophagus (RPKM 16.4) and 24 other tissues.

功能概要

肌球蛋白磷酸酶靶亚基 1，也称为肌球蛋白磷酸酶的肌球蛋白结合亚基，是肌球蛋白磷酸酶的亚基之一。肌球蛋白磷酸酶调节鸟苷三磷酸酶 Rho 下游的肌动蛋白和肌球蛋白的相互作用。小鸟苷三磷酸酶 Rho 与肌球蛋白轻链 (MLC) 磷酸化有关，这会导致平滑肌收缩以及非肌肉细胞中肌动蛋白和肌球蛋白的相互作用。三磷酸鸟苷 (GTP) 结合的活性形式 RhoA (GTP.RhoA) 与肌球蛋白磷酸酶的肌球蛋白结合亚基 (MBS) 特异性相互作用，后者调节 MLC 的磷酸化程度。 Rho 相关激酶 (Rho-kinase) ，由 GTP 激活。 RhoA、磷酸化 MBS 并因此使肌球蛋白磷酸酶失活。 NIH 3T3 细胞中 RhoA 的过表达或激活的 RhoA 增加了 MBS 和 MLC 的磷酸化。因此，Rho 似乎通过 Rho 激酶的作用抑制肌球蛋白磷酸酶。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2009 年 1 月]

Myosin Phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin Phosphatase, is one of the subunits of myosin Phosphatase. Myosin Phosphatase regulates the interaction of actin and Myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in Myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and Myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin Phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin Phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin Phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

PPP1R12A 基因产物(5)

mRNA	Protein	Name
NM_001143885.2	NP_001137357.1	protein phosphatase 1 regulatory subunit 12A isoform a
NM_001143886.2	NP_001137358.1	protein phosphatase 1 regulatory subunit 12A isoform b
NM_001244990.2	NP_001231919.1	protein phosphatase 1 regulatory subunit 12A isoform c
NM_001244992.1	NP_001231921.1	protein phosphatase 1 regulatory subunit 12A isoform d
NM_002480.3	NP_002471.1	protein phosphatase 1 regulatory subunit 12A isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 14-3-3 protein binding	IDA IDA: 通过直接分析推断	20354225	GOA
enables enzyme inhibitor activity	IDA IDA: 通过直接分析推断	19245366	GOA
enables phosphatase regulator activity	IDA IDA: 通过直接分析推断	20354225	GOA
enables phosphatase regulator activity	IMP IMP: 通过突变表型推断	18477460	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11067852	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	18477460	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in centrosome cycle	IMP IMP: 通过突变表型推断	18477460	GOA
involved in mitotic cell cycle	IMP IMP: 通过突变表型推断	18477460	GOA
involved in negative regulation of catalytic activity	IDA IDA: 通过直接分析推断	19245366	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19245366	GOA
involved in protein dephosphorylation	IMP IMP: 通过突变表型推断	18477460	GOA
involved in regulation of cell adhesion	IDA IDA: 通过直接分析推断	20354225	GOA
NOT involved in regulation of establishment of endothelial barrier	IMP IMP: 通过突变表型推断	25816133	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of PTW/PP1 phosphatase complex	IDA IDA: 通过直接分析推断	20354225	GOA
located in centrosome	IDA IDA: 通过直接分析推断	18477460	GOA
located in contractile muscle fiber	IDA IDA: 通过直接分析推断	20634291	GOA
located in kinetochore	IDA IDA: 通过直接分析推断	18477460	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP1R12A 蛋白结构

Ank_2

0
200
400
600
800
1030 a.a.

蛋白主名

其他名称

protein phosphatase 1 regulatory subunit 12A

myosin binding subunit

PPP1R12A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PPP1R12A	O14974	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053
种属内	PPP1R12A	O14974	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
种属内	PPP1R12A	O14974	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
种属内	PPP1R12A	O14974	DAPK3	Homo sapiens	O43293	Anti Bait CoIP	15292222
种属内	PPP1R12A	O14974	DAPK3	Homo sapiens	O43293	Pull Down	15292222
种属间	PPP1R12A	O14974	CPI17	Sus scrofa	O18734	Pull Down	18073109

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Genitourinary And/Or Brain Malformation Syndrome

GUBS	Genitourinary And/Or/Brain Malformation Syndrome

Moebius Syndrome

Mobius Syndrome	Moebius Sequence
Oromandibular-Limb Hypogenesis Spectrum	Congenital Facial Diplegia
MBS	Moebius Congenital Oculofacial Paralysis
Absence Or Underdevelopment Of The 6th And 7th Cranial Nerves	Congenital Facial Diplegia Syndrome
Congenital Oculofacial Paralysis	Congenital Ophthalmoplegia And Facial Paresis
Moebius Spectrum	Möbius Sequence
Möbius Syndrome	Mobius Ii Syndrome

Coronary Artery Vasospasm

Coronary Vasospasm

Coronary Artery Spasm

Anencephaly

Aprosencephaly	Anencephalus
Congenital Absence Of Brain	Absence Of A Large Part Of The Brain And The Skull
Anencephalia	Anencephalic Monster
Brain Absence	Brain Agenesis
Brain Aplasia	Absent Brain
Anencephalic	Congenital Absence Of Cerebrum
Congenital Hemicrania	Incomplete Anencephaly

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Portal Hypertension

Hypertension, Portal	Hypertension Portal
Pht - [Portal Hypertension]	Portal Htn

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10978	PPP1R12A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PPP1R12A	VGNC	VGNC:68407
Canis familiaris	PPP1R12A	VGNC	VGNC:44878
Macaca mulatta	PPP1R12A	VGNC	VGNC:76362
Rattus norvegicus	PPP1R12A	RGD	RGD:620013
Mus musculus	PPP1R12A	MGD	MGI:1309528
Bos taurus	PPP1R12A	VGNC	VGNC:33223

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PPP1R12A - protein phosphatase 1 regulatory subunit 12A Gene

关于 PPP1R12A

功能概要

PPP1R12A 基因产物(5)

PPP1R12A 蛋白结构

PPP1R12A 蛋白互作信息

关联疾病

直系同源

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PPP1R12A - protein phosphatase 1 regulatory subunit 12A Gene

关于 PPP1R12A

功能概要

PPP1R12A 基因产物(5)

PPP1R12A 蛋白结构

PPP1R12A 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z