2. Gene
  3. Il18 - interleukin 18 Gene

Il18 - interleukin 18 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Igif; Il-18

基因 ID: 16173 | 基因类型: protein coding

关于 Il18

功能概要

Enables cytokine activity. Involved in lipid homeostasis; positive regulation of cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including interleukin-18-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; and positive regulation of interferon-gamma production. Located in extracellular space. Is expressed in several structures, including back skin; dorsal aorta; gut; lymphatic system; and reproductive system. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18). [provided by Alliance of Genome Resources, Apr 2022]

Il18 基因产物(3)

mRNA Protein Name
NM_001357221.1 NP_001344150.1 interleukin-18 isoform a
NM_001357222.1 NP_001344151.1 interleukin-18 isoform b
NM_008360.2 NP_032386.1 interleukin-18 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytokine activity IDA
IDA: 通过直接分析推断
11894098 MGI
enables cytokine activity IMP
IMP: 通过突变表型推断
12829194 MGI
enables receptor ligand activity IDA
IDA: 通过直接分析推断
10227969 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within T-helper 1 cell cytokine production IDA
IDA: 通过直接分析推断
15843532 MGI
acts upstream of or within T-helper 1 cell cytokine production IGI
IGI: 通过遗传相互作用推断
15843532 MGI
acts upstream of or within cell population proliferation IDA
IDA: 通过直接分析推断
15843532 MGI
acts upstream of or within cell population proliferation IGI
IGI: 通过遗传相互作用推断
15843532 MGI
involved in cholesterol homeostasis IMP
IMP: 通过突变表型推断
12829194 MGI
involved in defense response to Gram-positive bacterium IDA
IDA: 通过直接分析推断
30392956 MGI
involved in establishment of skin barrier IMP
IMP: 通过突变表型推断
26638073 MGI
acts upstream of or within inflammatory response IGI
IGI: 通过遗传相互作用推断
23132931 MGI
acts upstream of or within interleukin-18-mediated signaling pathway IDA
IDA: 通过直接分析推断
15843532 MGI
involved in interleukin-18-mediated signaling pathway IDA
IDA: 通过直接分析推断
30392956 MGI
acts upstream of or within interleukin-6 production IDA
IDA: 通过直接分析推断
15843532 MGI
acts upstream of or within natural killer cell activation IDA
IDA: 通过直接分析推断
10227969 MGI
acts upstream of or within natural killer cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
15843532 MGI
acts upstream of or within negative regulation of myoblast differentiation IMP
IMP: 通过突变表型推断
23844157 MGI
acts upstream of or within neutrophil activation IDA
IDA: 通过直接分析推断
15843532 MGI
involved in positive regulation of T-helper 2 cell differentiation IMP
IMP: 通过突变表型推断
12829194 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
26656097 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: 通过直接分析推断
19666510 MGI
involved in positive regulation of inflammatory response IMP
IMP: 通过突变表型推断
26638073 MGI
involved in positive regulation of macrophage derived foam cell differentiation IMP
IMP: 通过突变表型推断
12829194 MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
10227969 MGI
acts upstream of or within positive regulation of type II interferon production IDA
IDA: 通过直接分析推断
10227969 MGI
acts upstream of or within positive regulation of type II interferon production IGI
IGI: 通过遗传相互作用推断
15843532 MGI
involved in positive regulation of type II interferon production IMP
IMP: 通过突变表型推断
11907086 MGI
involved in triglyceride homeostasis IMP
IMP: 通过突变表型推断
12829194 MGI
acts upstream of type II interferon production IDA
IDA: 通过直接分析推断
10227969 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in extracellular space IDA
IDA: 通过直接分析推断
30392956 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
15220916 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interleukin-18

IFN-gamma-inducing factor

IL-1 gamma

interferon gamma-inducing factor

interleukin-1 gamma

重组 Il18 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70642 IL-18 Protein, Mouse (His) P70380 (N36-S192) ≥95%
HY-P73181 IL-18 Protein, Mouse (solution) P70380 (N36-S192) ≥95%
HY-P70642AF Animal-Free IL-18 Protein, Mouse (His) P70380 (N36-S192) ≥95%

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-13205 Belnacasan Inhibitor 99.99% Phase 2
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P990591 GSK-1070806 Inhibitor 99.50% Phase 2
HY-P99491 Camoteskimab Inhibitor 98.41% Phase 1
Pre-clinical Phase
生物活性分子 (23)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16990 Ac-YVAD-cmk Inhibitor 98.94% 否
HY-101092 QS-21 Activator 99.67% 否
HY-123879 BAA473 98.93% 否
HY-156413 NLRP3 agonist 1 Agonist 99.01% 否
HY-19676 Pralnacasan Inhibitor 99.83% 否
HY-150742 ODN 2336 Agonist 90.74% 否
HY-149478 JT002 Inhibitor 99.49% 否
HY-W176629 Hydrocotarnine Inhibitor 99.59% 否
HY-147660 IMMH001 Agonist 98.10% 否
HY-130413 Protectin D1 99.10% 否
HY-102019 NSC61610 Inhibitor 99.50% 否
HY-160793 NSC80734 Inhibitor 98.08% 否
HY-164426 HEI3090 Activator 99.04% 否
HY-150742A ODN 2336 sodium 90.74% 否
HY-158024A (S)-NDT-19795 Inhibitor / 否
HY-W269593 Perfluorodecanoic acid Inhibitor / 否
HY-111662 Fc 11a-2 Inhibitor / 否
HY-130480 Fructose-arginine Inhibitor / 否
HY-RS06708 IL18 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06709 IL18BP Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06710 IL18R1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06711 IL18RAP Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-119337 CE-2072 Inhibitor / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990312 ABT-325 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il18 NCBI NCBI:3606
Canis lupus familiaris Il18 NCBI
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