2. Gene
  3. Il1r1 - interleukin 1 receptor, type I Gene

Il1r1 - interleukin 1 receptor, type I Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: IL-iR; CD121a; CD121b; IL-1R1; Il1r-1; IL-1R-1; IL-1RT1; IL-1RT-1; IL-1R-alpha

基因 ID: 16177 | 基因类型: protein coding

关于 Il1r1

功能概要

Enables interleukin-1 binding activity; interleukin-1 receptor activity; and protease binding activity. Involved in interleukin-1-mediated signaling pathway. Acts upstream of or within several processes, including cytokine-mediated signaling pathway; positive regulation of interleukin-1-mediated signaling pathway; and positive regulation of neutrophil extravasation. Located in external side of plasma membrane. Is expressed in brain; dorsal aorta; liver; reproductive system; and spleen. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in systemic scleroderma and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Il1r1 基因产物(4)

mRNA Protein Name
NM_001123382.2 NP_001116854.1 interleukin-1 receptor type 1 isoform 2 precursor
NM_008362.3 NP_032388.1 interleukin-1 receptor type 1 isoform 1 precursor
NM_001123382.2 NP_001116854.1 interleukin-1 receptor type 1 isoform 2 precursor
NM_008362.3 NP_032388.1 interleukin-1 receptor type 1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables interleukin-1 binding IPI
IPI: 通过物理相互作用推断
23395675 MGI
enables interleukin-1 receptor activity IDA
IDA: 通过直接分析推断
10854325 MGI
enables interleukin-1 receptor activity IMP
IMP: 通过突变表型推断
23395675 MGI
enables protease binding IPI
IPI: 通过物理相互作用推断
12135759 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
1828071 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: 通过直接分析推断
11880380 MGI
involved in interleukin-1-mediated signaling pathway IDA
IDA: 通过直接分析推断
10854325 MGI
acts upstream of or within positive regulation of interleukin-1-mediated signaling pathway IMP
IMP: 通过突变表型推断
23395675 MGI
acts upstream of or within positive regulation of neutrophil extravasation IMP
IMP: 通过突变表型推断
23395675 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: 通过突变表型推断
22297845 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
19833765 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
23034280 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interleukin-1 receptor type 1

CD121 antigen-like family member A

IL-1 receptor alpha chain

interleukin-1 receptor alpha

重组 Il1r1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70286 IL-1R1 Protein, Mouse (HEK293, His) P13504 (L20-K338) ≥95%

相关产品

Approval
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-108841 Raleukin Antagonist 99.40% 否
HY-108822 Rilonacept Inhibitor ≥95.0% 否
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P1110 AF12198 Inhibitor 99.75% 否
HY-RS06720 IL1R1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-P10474 RYTVELA / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99140 Anti-Mouse IL-1R Antibody (JAMA-147) Inhibitor 95.00% 否
HY-P990321 AMG-108 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il1r1 NCBI NCBI:3554
Macaca fascicularis Il1r1 NCBI NCBI:102146317
Rattus norvegicus Il1r1 NCBI NCBI:25663
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