1. Gene
  2. EXD1 - exonuclease 3'-5' domain containing 1 Gene

EXD1 - exonuclease 3'-5' domain containing 1 Gene

中文名称:含核酸外切酶 3'-5' 结构域 1

种属: Homo sapiens

同用名: EXDL1

基因 ID: 161829 | 基因类型: protein coding

关于 EXD1

This gene has 5 transcripts (splice variants), 182 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 6.1).

功能概要

预测可实现 RNA 结合活性和蛋白质同源二聚化活性。预测通过 RNA 和 piRNA 代谢过程参与基因沉默。预测位于 P 粒。预计成为 PET 复合体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable RNA binding activity and protein homodimerization activity. Predicted to be involved in gene silencing by RNA and piRNA metabolic process. Predicted to be located in P granule. Predicted to be part of PET complex. [provided by Alliance of Genome Resources, Apr 2022]

EXD1 基因产物(3)

mRNA Protein Name
NM_001286441.2 NP_001273370.1 piRNA biogenesis protein EXD1 isoform 1
NM_001385036.1 NP_001371965.1 piRNA biogenesis protein EXD1 isoform 3
NM_152596.4 NP_689809.2 piRNA biogenesis protein EXD1 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

EXD1 蛋白结构

DNA_pol_A_exo1

DNA_pol_A_exo1: 3'-5' exonuclease (85 - 210)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 514 a.a.
蛋白主名 其他名称

piRNA biogenesis protein EXD1

exonuclease 3'-5' domain-containing protein 1

EXD1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EXD1 Q8NHP7 EML2 Homo sapiens O95834
Y2H Array
25416956
种属内
EXD1 Q8NHP7 EML2 Homo sapiens O95834
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cerebral Creatine Deficiency Syndrome 3

Arginine:Glycine Amidinotransferase Deficiency

Agat Deficiency

Gatm Deficiency

Creatine Deficiency Syndrome Due To Agat Deficiency

L-Arginine:Glycine Amidinotransferase Deficiency

CCDS3

L-Arginine:Glycine Aminidotransferase Deficiency

Deficiency, Cerebral Creatine, Syndrome, Type 3

Cerebral Creatine Deficiency Syndrome

Deficiency, Cerebral Creatine, Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus EXD1 VGNC VGNC:61995
Macaca mulatta EXD1 VGNC VGNC:72390
Bos taurus EXD1 VGNC VGNC:28639
Canis familiaris EXD1 VGNC VGNC:40508
Rattus norvegicus EXD1 RGD RGD:1561009
Mus musculus EXD1 MGD MGI:3045306