IFNLR1 - interferon lambda receptor 1 Gene

中文名称：干扰素λ受体 1

种属: Homo sapiens

同用名: IFNLR; LICR2; IL28RA; CRF2/12; IL-28R1

基因 ID: 163702 | 基因类型: protein coding

关于 IFNLR1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:24,154,168-24,187,289 (from NCBI)

This gene has 5 transcripts (splice variants), 161 orthologues and 11 paralogues. Broad expression in small intestine (RPKM 5.6), lymph node (RPKM 4.0) and 22 other tissues.

功能概要

该基因编码的蛋白质属于 II 类细胞因子受体家族。这种蛋白质与白细胞介素 10 受体 β (IL10RB) 形成受体复合物。受体复合物已被证明与三种密切相关的细胞因子相互作用，包括白细胞介素 28A (IL28A) 、白细胞介素 28B (IL28B) 和白细胞介素 29 (IL29) 。病毒感染可诱导所有三种细胞因子的表达。已发现过表达该蛋白的细胞对 IL28A 和 IL29 的反应增强，但对 IL28B 的反应降低。已经报道了编码不同亚型的三种可变剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral Infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

IFNLR1 基因产物(3)

mRNA	Protein	Name
NM_170743.4	NP_734464.1	interferon lambda receptor 1 isoform 1 precursor
NM_173064.3	NP_775087.1	interferon lambda receptor 1 isoform 2
NM_173065.3	NP_775088.1	interferon lambda receptor 1 isoform 3 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	12469119	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of cellular respiration	IMP IMP: 通过突变表型推断	25930096	GOA
involved in regulation of defense response to virus by host	IDA IDA: 通过直接分析推断	12469119	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of interleukin-28 receptor complex	IDA IDA: 通过直接分析推断	12469119	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IFNLR1 蛋白结构

Tissue_fac

0
100
200
300
400
520 a.a.

蛋白主名

其他名称

interferon lambda receptor 1

CRF2-12

IFNLR1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	IFNLR1	Q8IU57	ANKRD46	Homo sapiens	Q86W74-2	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Psoriasis 12

PSORS12	Psoriasis Susceptibility 12
Psoriasis 12, Susceptibility To

Zika Virus Congenital Syndrome

Zikv Congenital Infection

Immunodeficiency 27a

IMD27A	Autosomal Recessive Ifngr1 Deficiency
Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis	Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency
Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency	Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency
Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency	Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive
Ifngr1 Deficiency, Autosomal Recessive	Immunodeficiency 27a, Mycobacteriosis, Ar
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency	Msmd Due To Complete Ifngammar1 Deficiency
Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency
Familial Disseminated Atypical Mycobacterial Infection	Interferon Gamma, Receptor 1, Deficiency
Immunodeficiency, Type 27a, Mycobacteriosis, Ar	Mycobacterial Disease, Mendelian Susceptibility To

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06595	IFNLR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	IFNLR1	MGD	MGI:2429859
Canis familiaris	IFNLR1	VGNC	VGNC:41881
Rattus norvegicus	IFNLR1	RGD	RGD:1562689
Felis catus	IFNLR1	VGNC	VGNC:107564
Bos taurus	IFNLR1	VGNC	VGNC:30061
Macaca mulatta	IFNLR1	VGNC	VGNC:73415
Others	IFNLR1	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4