AKR1C1 - aldo-keto reductase family 1 member C1 Gene

中文名称：醛酮还原酶家族 1 成员 C1

种属: Homo sapiens

同用名: C9; DD1; DDH; DDH1; H-37; HBAB; MBAB; HAKRC; DD1/DD2; 2-ALPHA-HSD; 20-ALPHA-HSD

基因 ID: 1645 | 基因类型: protein coding

关于 AKR1C1

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:4,963,415-4,983,283 (from NCBI)

This gene has 5 transcripts (splice variants), 491 orthologues and 16 paralogues. Biased expression in liver (RPKM 85.2), fat (RPKM 74.3) and 13 other tissues.

功能概要

该基因编码醛/酮还原酶超家族的一个成员，该家族由 40 多种已知的酶和蛋白质组成。这些酶利用 NADH 和/或 NADPH 作为辅助因子，催化醛和酮转化为其相应的醇。这些酶显示重叠但不同的底物特异性。这种酶催化黄体酮与非活性形式 20-α-羟基-黄体酮的反应。该基因与其他三个基因成员具有高度序列同一性，并与染色体 10p15-p14 上的这三个基因聚集在一起。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known Enzymes and proteins. These Enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The Enzymes display overlapping but distinct substrate specificity. This Enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three Other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

AKR1C1 基因产物(1)

mRNA	Protein	Name
NM_001353.6	NP_001344.2	aldo-keto reductase family 1 member C1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables aldose reductase (NADPH) activity	IDA IDA: 通过直接分析推断	21232532	GOA
enables androsterone dehydrogenase (B-specific) activity	IDA IDA: 通过直接分析推断	8486699	GOA
enables bile acid binding	IDA IDA: 通过直接分析推断	8486699	GOA
enables carboxylic acid binding	IDA IDA: 通过直接分析推断	8486699	GOA
enables ketosteroid monooxygenase activity	IDA IDA: 通过直接分析推断	21232532	GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA IDA: 通过直接分析推断	19442656	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	IDA IDA: 通过直接分析推断	8486699	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in bile acid metabolic process	IDA IDA: 通过直接分析推断	8486699	GOA
involved in cellular response to jasmonic acid stimulus	IDA IDA: 通过直接分析推断	19487289	GOA
involved in daunorubicin metabolic process	IMP IMP: 通过突变表型推断	20837989	GOA
involved in digestion	IDA IDA: 通过直接分析推断	8486699	GOA
involved in doxorubicin metabolic process	IMP IMP: 通过突变表型推断	20837989	GOA
involved in epithelial cell differentiation	IDA IDA: 通过直接分析推断	21492153	GOA
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: 通过直接分析推断	19442656	GOA
involved in progesterone metabolic process	IDA IDA: 通过直接分析推断	21232532	GOA
involved in response to organophosphorus	IEP IEP: 通过表达模式推断	16079077	GOA
involved in retinal metabolic process	IDA IDA: 通过直接分析推断	21851338	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	8486699	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AKR1C1 蛋白结构

Aldo_ket_red

0
100
200
300
323 a.a.

蛋白主名

其他名称

aldo-keto reductase family 1 member C1

20 alpha-hydroxysteroid dehydrogenase

AKR1C1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	AKR1C1	Q04828	PTPN3	Homo sapiens	P26045	Y2H Prey Pooling	32296183
种属内	AKR1C1	Q04828	PTPN3	Homo sapiens	P26045	Validated Y2H	25416956
种属内	AKR1C1	Q04828	PTPN3	Homo sapiens	P26045	Y2H Array	25416956
种属内	AKR1C1	Q04828	AKR1D1	Homo sapiens	P51857	Anti Tag CoIP	33961781
种属内	AKR1C1	Q04828	AKR1D1	Homo sapiens	P51857	Anti Tag CoIP	28514442
种属内	AKR1C1	Q04828	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	AKR1C1	Q04828	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	AKR1C1	Q04828	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

AKR1C1 抗体

目录号	产品名	应用	反应物种
HY-P82930	AKR1C1/AKR1C2 Antibody (YA2675)	WB, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Developmental Dysplasia Of The Hip 1

Acetabular Dysplasia	Developmental Dysplasia Of The Hip
DDH1	Hip Dysplasia, Developmental
Ddh	Hip Dysplasia, Congenital
Cdh	Congenital Hip Dislocation Nos

Lipedema

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Lung Benign Neoplasm

Lung Neoplasms	Tumor Of The Lung
Lung Tumor

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2	Acromegaly Due To Pituitary Adenoma 2
Acromegaly, X-Linked	Growth Hormone Secreting Pituitary Adenoma 2
Pituitary Adenoma, Growth Hormone-Secreting, 2	Pituitary Adenoma 2, Gh-Secreting
Gh-Secreting Pituitary Adenoma 2	X-Linked Acromegaly
Adenoma, Pituitary, Growth Hormone-Secreting, Type 2

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N0376	Liquiritin		99.68%	否
HY-150644	S07-2010	Inhibitor	99.79%	否
HY-D1341	Coumberone		99.95%	否
HY-114009	AKR1C1-IN-1		99.38%	否
HY-118819	5-Bromo-3-phenyl salicylic acid	Inhibitor	/	否
HY-113850	CPSA	Inhibitor	/	否
HY-163609	PROTAC AKR1C3 degrader-1	Degrader	/	否
HY-N0376R	Liquiritin (Standard)		/	否
HY-RS00534	AKR1C1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	AKR1C1	RGD	RGD:1306847

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4