DCLK2 - doublecortin like kinase 2 Gene

中文名称：双皮质素样激酶 2

种属: Homo sapiens

同用名: CL2; DCK2; CLIK2; DCDC3; CLICK2; DCDC3B; DCAMKL2; CLICK-II

关于 DCLK2

功能概要

该基因编码蛋白激酶超家族和双皮质素家族的成员。该基因编码的蛋白质包含两个 N 端双皮质素结构域，可结合微管并调节微管聚合，一个 C 端丝氨酸/苏氨酸蛋白激酶结构域，与 Ca2+/钙调蛋白依赖性蛋白激酶具有显着同源性，以及一个丝氨酸/双皮质素和蛋白激酶结构域之间富含脯氨酸的结构域，介导多种蛋白质-蛋白质相互作用。编码蛋白的微管聚合活性与其蛋白激酶活性无关。小鼠研究表明，另一个家族成员 DCX 基因和该基因在海马组织的建立中具有相同的功能，并且它们的缺失会导致严重的癫痫表型和致死率，如人类无脑回畸形患者所描述的那样。已经鉴定出多个选择性剪接的转录本变体。[RefSeq 提供，2010 年 9 月]

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]