2. Gene
  3. Ldha - lactate dehydrogenase A Gene

Ldha - lactate dehydrogenase A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ldh1; Ldhm; l7R2

基因 ID: 16828 | 基因类型: protein coding

关于 Ldha

功能概要

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the Lactate Dehydrogenase family. Mutations in this gene have been linked to hemolytic anemia and early postimplantation death in mice. Multiple transcript variants encoding different isoforms have been found for this gene. The mouse genome contains multiple pseudogenes of this gene. [provided by RefSeq, May 2013]

Ldha 基因产物(2)

mRNA Protein Name
NM_001136069.2 NP_001129541.2 L-lactate dehydrogenase A chain isoform 2
NM_010699.2 NP_034829.1 L-lactate dehydrogenase A chain isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-lactate dehydrogenase activity IDA
IDA: 通过直接分析推断
7323947 MGI
enables L-lactate dehydrogenase activity IMP
IMP: 通过突变表型推断
3796661 MGI
enables lactate dehydrogenase activity IMP
IMP: 通过突变表型推断
8224816 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12107167 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within glucose catabolic process to lactate via pyruvate IMP
IMP: 通过突变表型推断
8224816 MGI
involved in pyruvate catabolic process IDA
IDA: 通过直接分析推断
21041631 MGI
involved in pyruvate catabolic process IMP
IMP: 通过突变表型推断
8224816 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytosol IDA
IDA: 通过直接分析推断
17572440 MGI
located in cytosol IDA
IDA: 通过直接分析推断
11980919 MGI
located in sperm fibrous sheath IDA
IDA: 通过直接分析推断
16687649 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

L-lactate dehydrogenase A chain

LDH muscle subunit

LDH-M

M-LDH

lactate dehydrogenase 1, A chain

lactate dehydrogenase A4

重组 Ldha 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70259 LDHA Protein, Mouse (HEK293, His) P06151 (M1-F332) ≥95%
HY-P73270 LDHA Protein, Mouse (His) P06151 (M1-F332) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (24)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W013032A Oxamic acid sodium 99.72% 否
HY-100681 GSK2837808A Inhibitor ≥99.0% 否
HY-16214 FX-11 99.21% 否
HY-100742A (R)-GNE-140 Inhibitor 99.73% 否
HY-W040118 Galloflavin Inhibitor 99.36% 否
HY-139319 LDHA-IN-3 Inhibitor 99.88% 否
HY-18968 LDHA-IN-4 Inhibitor 98.06% 否
HY-100742 GNE-140 racemate Inhibitor 99.38% 否
HY-111108 LDH-IN-1 Inhibitor 99.84% 否
HY-W013032 Oxamic acid 99.98% 否
HY-124309 NHI-2 Inhibitor 99.30% 否
HY-100742B (S)-GNE-140 Inhibitor 99.07% 否
HY-156683 CHK-336 Inhibitor 98.05% 否
HY-147361 LDCA 99.18% 否
HY-152261 MS6105 99.2% 否
HY-115875 LDHA-IN-5 Inhibitor / 否
HY-146977 LDHA/PDKs-IN-1 Inhibitor / 否
HY-146978 LDHA/PDKs-IN-2 Inhibitor / 否
HY-162627 LDHA-IN-6 Inhibitor / 否
HY-162629 LDHA-IN-7 Inhibitor / 否
HY-168733 LDHA-IN-9 / 否
HY-169060 LDHA-IN-8 Inhibitor / 否
HY-169061 WQQ-345 / 否
HY-RS07571 LDHA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ldha NCBI NCBI:3939
Rattus norvegicus Ldha NCBI NCBI:24533
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