2. Metabolic Enzyme/Protease Apoptosis
  3. Lactate Dehydrogenase Apoptosis
  4. Oxamic acid

Oxamic acid  (Synonyms: 草氨酸; Oxamidic acid)

目录号: HY-W013032 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Oxamic acid 是一种 LDH-A (乳酸脱氢酶-A) 抑制剂。Oxamic acid 表现出抗肿瘤活性，对癌细胞的抗增殖活性，并可诱导细胞凋亡。

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Oxamic acid Chemical Structure

Oxamic acid Chemical Structure

CAS No. : 471-47-6

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规格 价格 是否有货
100 mg ￥210
询问价格 & 货期
500 mg ￥245
询问价格 & 货期

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Oxamic acid 的其他形式现货产品:

Customer Review

Other Forms of Oxamic acid:

Oxamic acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Oxamic acid is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3].

体外研究
(In Vitro)

Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells[1].
Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells[2].
Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells[2].
Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells[2].
Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Oxamic acid 相关抗体:

Cell Proliferation Assay[2]

Cell Line: CNE-1 and CNE-2 cells
Concentration: 10 μM
Incubation Time: 24-72 hours
Result: Showed IC50s of 74.6, 32.4 and 17.8 mM and 62.3, 44.5, 31.6 mM at 24, 48 and 72 h in the CNE-1 and CNE-2 cancer cells, respectively.

Apoptosis Analysis[2]

Cell Line: CNE-1 and CNE-2 cells
Concentration: 0, 20, 50 and 100 mM
Incubation Time: 48 hours
Result: Showed the increasement of early and late apoptotic cells in a dose-dependent manner.
Increased the expression of pro-apoptotic Bax and cleaved-caspase-3, while reduced the anti-apoptotic signals of Bcl-2 and pro-caspase-3.

Cell Cycle Analysis[2]

Cell Line: CNE-1 and CNE-2 cells
Concentration: 0, 20, 50 and 100 mM
Incubation Time: 24 hours
Result: Showed a dose-dependent increase in the numbers of CNE-1 and CNE-2 cells in the G2/M phase.
体内研究
(In Vivo)

Oxamic acid (intraperitoneal injection; 750 mg/kg; once daily; 3 w) treatment improves the efficacy of tumor inhibition in vivo when combined with irradiation treatment[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c nude mice injected with CNE-1 cells[2]
Dosage: 750 mg/kg
Administration: Intraperitoneal injection; 750 mg/kg; once daily; 3 weeks
Result: Inhibited the tumor growth when compared to either oxamate alone or irradiation alone.
分子量

89.05

Formula

C2H3NO3
CAS 号
性状

固体

颜色

White to off-white

中文名称

草氨酸； 乙酰胺酸
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

H2O 中的溶解度 : 100 mg/mL (1122.96 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 11.2296 mL 56.1482 mL 112.2965 mL
5 mM 2.2459 mL 11.2296 mL 22.4593 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.98%

COA (282 KB) RP-HPLC (293 KB)

产品使用指南 (1538 KB)
参考文献

Oxamic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 11.2296 mL 56.1482 mL 112.2965 mL 280.7411 mL
5 mM 2.2459 mL 11.2296 mL 22.4593 mL 56.1482 mL
10 mM 1.1230 mL 5.6148 mL 11.2296 mL 28.0741 mL
15 mM 0.7486 mL 3.7432 mL 7.4864 mL 18.7161 mL
20 mM 0.5615 mL 2.8074 mL 5.6148 mL 14.0371 mL
25 mM 0.4492 mL 2.2459 mL 4.4919 mL 11.2296 mL
30 mM 0.3743 mL 1.8716 mL 3.7432 mL 9.3580 mL
40 mM 0.2807 mL 1.4037 mL 2.8074 mL 7.0185 mL
50 mM 0.2246 mL 1.1230 mL 2.2459 mL 5.6148 mL
60 mM 0.1872 mL 0.9358 mL 1.8716 mL 4.6790 mL
80 mM 0.1404 mL 0.7019 mL 1.4037 mL 3.5093 mL
100 mM 0.1123 mL 0.5615 mL 1.1230 mL 2.8074 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxamic acid471-47-6Oxamidic acid草氨酸 乙酰胺酸Lactate DehydrogenaseApoptosisLDHanti-tumor activityanti-proliferative activityinduce apoptosisCNE-1CNE-2A2780SKOV3Inhibitorinhibitorinhibit

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