Limk1 - LIM-domain containing, protein kinase Gene

中文名称：含 LIM 结构域的蛋白激酶

种属: Mus musculus

同用名: Limk; KIZ-1; LIMK-1

关于 Limk1

功能概要

该基因编码 LIM 激酶蛋白家族的成员。这种蛋白质是一种丝氨酸/苏氨酸激酶，通过肌动蛋白结合因子肌动蛋白丝切蛋白的磷酸化和失活来调节肌动蛋白聚合。这种蛋白质还可以刺激轴突生长，并可能在大脑发育中发挥作用。该基因的纯合基因敲除小鼠表现出骨量减少、神经元形态异常和突触功能改变。已鉴定出该基因的多个假基因。可变剪接导致多个转录本变体。 [RefSeq 提供，2015 年 4 月]

This gene encodes a member of the LIM kinase family of proteins. This protein is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein also stimulates axon growth and may play a role in brain development. Homozygous knockout mice for this gene exhibit reduced bone mass, abnormal neuronal morphology and altered synaptic function. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]