2. Gene
  3. Prkcd - protein kinase C, delta Gene

Prkcd - protein kinase C, delta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 C， δ

种属: Rattus norvegicus

同用名: Pkcd

基因 ID: 170538 | 基因类型: protein coding

关于 Prkcd

Primary_assembly 16: 5,769,215-5,799,352 reverse strand.mRatBN7.2:CM026989.1

This gene has 3 transcripts (splice variants), 289 orthologues, 5 paralogues and is associated with 27 phenotypes. Biased expression in Lung (RPKM 21.4), Spleen (RPKM 28.8) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 TIR 域绑定活动；钙非依赖性蛋白激酶 C 活性；和蛋白激酶结合活性。参与多个过程，包括跨质膜导入 D-天冬氨酸； MAP 激酶活性的正调节；积极调节葡萄糖输入。位于几种细胞成分中，包括细胞质；线粒体；和核。在突触后细胞质中活跃。用于研究脑缺血和高血压。高胰岛素血症的生物标志物；高血压;肌肉疾病;肥胖;和限制性心肌病。该基因的人类直系同源物与自身免疫性淋巴增生综合征 3 型和脂肪肝疾病有关。与人 PRKCD（蛋白激酶 C δ）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables TIR domain binding activity; calcium-independent protein kinase C activity; and protein kinase binding activity. Involved in several processes, including D-aspartate import across plasma membrane; positive regulation of MAP kinase activity; and positive regulation of glucose import. Located in several cellular components, including cytosol; mitochondrion; and nucleus. Is active in postsynaptic cytosol. Used to study brain ischemia and hypertension. Biomarker of hyperinsulinism; hypertension; muscular disease; obesity; and restrictive cardiomyopathy. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3 and fatty liver disease. Orthologous to human PRKCD (protein kinase C delta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcd 基因产物(1)

mRNA Protein Name
NM_133307.2 NP_579841.2 protein kinase C delta type
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables TIR domain binding IPI
IPI: 通过物理相互作用推断
17161867 RGD
enables diacylglycerol-dependent serine/threonine kinase activity EXP
EXP: 通过实验结果推断
12198130 RGD
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IDA
IDA: 通过直接分析推断
1915352 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9514928 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
15337529 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in D-aspartate import across plasma membrane IMP
IMP: 通过突变表型推断
17364745 RGD
involved in apoptotic process IMP
IMP: 通过突变表型推断
21696630 RGD
involved in cellular response to glucose starvation IEP
IEP: 通过表达模式推断
17728702 RGD
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
17046201 RGD
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
21696630 RGD
involved in collagen metabolic process IMP
IMP: 通过突变表型推断
17728702 RGD
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
11562372 RGD
involved in positive regulation of D-glucose import IMP
IMP: 通过突变表型推断
17098211 RGD
involved in positive regulation of MAP kinase activity IMP
IMP: 通过突变表型推断
16935468 RGD
involved in positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
12790799 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
12663471 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
10085132 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
1915352 RGD
involved in regulation of phosphorylation IDA
IDA: 通过直接分析推断
21696630 RGD
involved in response to amino acid IEP
IEP: 通过表达模式推断
17210758 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
17728104 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
12960081 RGD
involved in response to hydrogen peroxide IEP
IEP: 通过表达模式推断
12226102 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
16936002 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
17487266 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
11478406 RGD
involved in response to oxidative stress IMP
IMP: 通过突变表型推断
11576956 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
17123493 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in postsynaptic cytosol IDA
IDA: 通过直接分析推断
8263228 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Prkcd 蛋白结构

C1_nPKC_theta-like_rpt1

C1_nPKC_theta-like_rpt1: cd20834 (151 - 211)

C1_nPKC_theta-like_rpt2

C1_nPKC_theta-like_rpt2: cd20837 (230 - 279)

PKc_like

PKc_like: cl21453 (350 - 665)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
蛋白主名 其他名称

protein kinase C delta type

nPKC-delta

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11122 PRKCD Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11123 Prkcd Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11124 Prkcd Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkcd NCBI NCBI:5580
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