2. Gene
  3. Il1rl1 - interleukin 1 receptor-like 1 Gene

Il1rl1 - interleukin 1 receptor-like 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1

基因 ID: 17082 | 基因类型: protein coding

关于 Il1rl1

功能概要

Enables interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including negative regulation of T-helper 1 type immune response; positive regulation of macrophage activation; and regulation of cytokine production. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in external side of plasma membrane and extracellular matrix. Is expressed in several structures, including immune system; musculoskeletal system; salivary gland; skin; and visual system. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1). [provided by Alliance of Genome Resources, Apr 2022]

Il1rl1 基因产物(3)

mRNA Protein Name
NM_001025602.3 NP_001020773.1 interleukin-1 receptor-like 1 isoform a precursor
NM_001294171.1 NP_001281100.1 interleukin-1 receptor-like 1 isoform b precursor
NM_010743.3 NP_034873.2 interleukin-1 receptor-like 1 isoform b precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables interleukin-33 binding IPI
IPI: 通过物理相互作用推断
29045903 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17675517 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in inflammatory response IMP
IMP: 通过突变表型推断
34644537 MGI
involved in macrophage differentiation IMP
IMP: 通过突变表型推断
34644537 MGI
involved in negative regulation of T-helper 1 type immune response IGI
IGI: 通过遗传相互作用推断
18268038 MGI
involved in negative regulation of type II interferon production IGI
IGI: 通过遗传相互作用推断
18268038 MGI
involved in positive regulation of chemokine production IMP
IMP: 通过突变表型推断
19841166 MGI
involved in positive regulation of inflammatory response IMP
IMP: 通过突变表型推断
19841166 MGI
involved in positive regulation of interleukin-5 production IGI
IGI: 通过遗传相互作用推断
18268038 MGI
involved in positive regulation of macrophage activation IMP
IMP: 通过突变表型推断
19841166 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
12714518 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interleukin-1 receptor-like 1

interleukin-33 receptor alpha chain

lymphocyte antigen 84

重组 Il1rl1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72459 ST2/IL1RL1 Protein, Mouse (HEK293, His) P14719-2 (S27-A337) ≥95%
HY-P76661 ST2/IL1RL1 Protein, Mouse (332a.a, HEK293, Fc) P14719 (M1-R332) ≥95%
HY-P76662 ST2/IL1RL1 Protein, Mouse (332a.a, HEK293, His) P14719 (M1-R332) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99729 Melrilimab Inhibitor 96.07% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06725 IL1RL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il1rl1 NCBI NCBI:9173
Macaca fascicularis Il1rl1 NCBI NCBI:102115135
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