2. Gene
  3. Cysltr2 - cysteinyl leukotriene receptor 2 Gene

Cysltr2 - cysteinyl leukotriene receptor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：半胱氨酰白三烯受体 2

种属: Rattus norvegicus

同用名: Cyslt2; RSBPT32

基因 ID: 170926 | 基因类型: protein coding

关于 Cysltr2

Primary_assembly 15: 48,189,073-48,304,136 reverse strand.mRatBN7.2:CM026988.1

This gene has 5 transcripts (splice variants), 55 orthologues, 13 paralogues and is associated with 12 phenotypes. Biased expression in Thymus (RPKM 57.3), Lung (RPKM 32.) and 4 other tissues.

功能概要

预计该基因编码的蛋白可启动 G 蛋白偶联肽受体活性和半胱氨酰白三烯受体活性。参与 ERK1 和 ERK2 级联的正向调控；血管生成的正向调节；和细胞死亡的正调节。预测位于膜中。预计是质膜的组成部分。该基因的人类直系同源物与阿司匹林诱发的呼吸系统疾病和哮喘有关。与人 CYSLTR2（半胱氨酰白三烯受体 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable G protein-coupled peptide receptor activity and cysteinyl Leukotriene Receptor activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of angiogenesis; and positive regulation of cell death. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease and asthma. Orthologous to human CYSLTR2 (cysteinyl Leukotriene Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cysltr2 基因产物(1)

mRNA Protein Name
NM_133413.2 NP_596904.1 cysteinyl leukotriene receptor 2
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
17910051 RGD
involved in negative regulation of glial cell proliferation IMP
IMP: 通过突变表型推断
17910051 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
21055410 RGD
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
21105577 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Cysltr2 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (23 - 299)

7tm_GPCRs

7tm_GPCRs: cd14964 (24 - 48)

7tm_GPCRs

7tm_GPCRs: cd14964 (57 - 78)

7tm_GPCRs

7tm_GPCRs: cd14964 (95 - 117)

7tm_GPCRs

7tm_GPCRs: cd14964 (140 - 156)

7tm_GPCRs

7tm_GPCRs: cd14964 (182 - 205)

7tm_GPCRs

7tm_GPCRs: cd14964 (229 - 251)

7tm_GPCRs

7tm_GPCRs: cd14964 (267 - 292)

  • 0
  • 100
  • 200
  • 309 a.a.
蛋白主名 其他名称

cysteinyl leukotriene receptor 2

cysteinyl leukotriene CysLT2 receptor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03497 CYSLTR2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03498 Cysltr2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03499 Cysltr2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cysltr2 NCBI NCBI:57105
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