Cx3cr1 - C-X3-C motif chemokine receptor 1 Gene

中文名称：C-X3-C 基序趋化因子受体 1

种属: Rattus norvegicus

同用名: Rbs11

关于 Cx3cr1

功能概要

该基因编码的蛋白可启动 C-X3-C 趋化因子受体活性。参与多个过程，包括细胞凋亡过程的负调控；调节细胞迁移；和基因表达的调控。位于多个细胞成分中，包括细胞表面；神经细胞体膜；和细胞质的核周区。用于研究帕金森症；肾小球肾炎;肝肺综合征;和癫痫持续状态。多种疾病的生物标志物，包括抗基底膜肾小球肾炎；动脉疾病（多发性）；博尔纳病；门静脉高压症;和坐骨神经病。该基因的人类直系同源物与多种疾病有关，包括人类免疫缺陷病毒传染病；肥胖;肺动脉高压;视网膜疾病（多发）；和系统性硬皮病。与人 CX3CR1（C-X3-C 基序趋化因子受体 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables C-X3-C Chemokine Receptor activity. Involved in several processes, including negative regulation of apoptotic process; regulation of cell migration; and regulation of gene expression. Located in several cellular components, including cell surface; neuronal cell body membrane; and perinuclear region of cytoplasm. Used to study Parkinsonism; glomerulonephritis; hepatopulmonary syndrome; and status epilepticus. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; artery disease (multiple); borna disease; portal hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including human immunodeficiency virus infectious disease; obesity; pulmonary hypertension; retinal disease (multiple); and systemic scleroderma. Orthologous to human CX3CR1 (C-X3-C motif Chemokine Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]