2. Gene
  3. CAMK2G - calcium/calmodulin-dependent protein kinase II gamma Gene

CAMK2G - calcium/calmodulin-dependent protein kinase II gamma Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：钙/钙调蛋白依赖性蛋白激酶 II γ

种属: Rattus norvegicus

基因 ID: 171140 | 基因类型: protein coding

关于 CAMK2G

Primary_assembly 15: 3,504,085-3,563,050 forward strand.mRatBN7.2:CM026988.1

This gene has 9 transcripts (splice variants), 297 orthologues, 21 paralogues and is associated with 4 phenotypes. Biased expression in Brain (RPKM 299.9), Muscle (RPKM 278.6) and 9 other tissues.

功能概要

该基因编码的蛋白可启动钙调蛋白依赖性蛋白激酶活性。参与多个过程，包括蛋白质自身磷酸化；调节蛋白质在质膜上的定位；和对缺氧的反应。预测位于突触后密度。预计是钙和钙调蛋白依赖性蛋白激酶复合物的一部分。预计在细胞质和神经元投射中具有活性。该基因的人类直系同源物与常染色体显性非综合征性智力障碍有关。与人 CAMK2G（钙/钙调蛋白依赖性蛋白激酶 II γ）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables calmodulin-dependent protein kinase activity. Involved in several processes, including protein autophosphorylation; regulation of protein localization to plasma membrane; and response to hypoxia. Predicted to be located in postsynaptic density. Predicted to be part of calcium- and calmodulin-dependent protein kinase complex. Predicted to be active in cytoplasm and neuron projection. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human CAMK2G (calcium/Calmodulin dependent protein kinase II gamma). [provided by Alliance of Genome Resources, Apr 2022]

CAMK2G 基因产物(1)

mRNA Protein Name
NM_133605.1 NP_598289.1 calcium/calmodulin-dependent protein kinase type II subunit gamma
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium/calmodulin-dependent protein kinase activity IDA
IDA: 通过直接分析推断
11925434 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
11925434 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: 通过直接分析推断
35290589 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
IMP: 通过突变表型推断
35290589 RGD
involved in regulation of protein localization to plasma membrane IGI
IGI: 通过遗传相互作用推断
19188609 RGD
involved in response to hypoxia IDA
IDA: 通过直接分析推断
11925434 RGD
involved in response to oxidative stress IDA
IDA: 通过直接分析推断
11925434 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
35290589 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
35290589 RGD
is active in postsynaptic cytosol IDA
IDA: 通过直接分析推断
35290589 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CAMK2G 蛋白结构

STKc_CaMKII

STKc_CaMKII: cd14086 (11 - 302)

CaMKII_AD

CaMKII_AD: pfam08332 (455 - 582)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 588 a.a.
蛋白主名 其他名称

calcium/calmodulin-dependent protein kinase type II subunit gamma

Ca+2/calmodulin-dependent protein kinase II gamma

caM kinase II subunit gamma

caM-kinase II gamma chain

caMK-II subunit gamma

calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma

calcium/calmodulin-dependent protein kinase type II gamma chain

calcium/calmodulin-dependent protein kinase type II subunit gamma-like

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01859 CAMK2G Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01860 Camk2g Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01861 CAMK2G Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens CAMK2G NCBI NCBI:818
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