2. Gene
  3. Mdk - midkine Gene

Mdk - midkine Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: MK; Mek

基因 ID: 17242 | 基因类型: protein coding

关于 Mdk

功能概要

This gene encodes a secreted growth factor that belongs to the pleiotrophin/midkine heparin-binding protein family and functions in a variety of biological processes. The encoded cytokine promotes the growth, differentiation, survival and migration of several target cells including leucocytes involved in inflammation. This protein plays a role in the formation of scar tissue and intraperitoneal adhesions, and promotes neurite outgrowth and neuron survival. The protein encoded by this gene is associated with obesity and inhibition of Insulin signaling in fat cells. A pseudogene of this gene is present on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Mdk 基因产物(6)

mRNA Protein Name
NM_001012335.3 NP_001012335.1 midkine isoform a precursor
NM_001012336.3 NP_001012336.1 midkine isoform a precursor
NM_001291481.2 NP_001278410.1 midkine isoform a precursor
NM_001291482.2 NP_001278411.1 midkine isoform b
NM_001291483.2 NP_001278412.1 midkine isoform c precursor
NM_010784.6 NP_034914.1 midkine isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chondroitin sulfate binding IDA
IDA: 通过直接分析推断
10978312 MGI
enables heparin binding IDA
IDA: 通过直接分析推断
10978312 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9089390 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell activation involved in immune response IMP
IMP: 通过突变表型推断
28183532 MGI
involved in behavioral fear response IMP
IMP: 通过突变表型推断
10096022 MGI
involved in cerebellar granular layer development IMP
IMP: 通过突变表型推断
10096022 MGI
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
10096022 MGI
involved in cytoskeleton organization IMP
IMP: 通过突变表型推断
16901907 MGI
involved in defecation IMP
IMP: 通过突变表型推断
10096022 MGI
involved in dentate gyrus development IEP
IEP: 通过表达模式推断
10096022 MGI
involved in estrous cycle IMP
IMP: 通过突变表型推断
17121547 MGI
involved in glial cell projection elongation IDA
IDA: 通过直接分析推断
16901907 MGI
involved in hippocampus development IMP
IMP: 通过突变表型推断
10096022 MGI
involved in leukocyte chemotaxis involved in inflammatory response IMP
IMP: 通过突变表型推断
10683378 MGI
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
21185956 MGI
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
17015789 MGI
involved in negative regulation of cell adhesion IDA
IDA: 通过直接分析推断
10978312 MGI
involved in negative regulation of epithelial cell apoptotic process IMP
IMP: 通过突变表型推断
15509530 MGI
involved in negative regulation of inflammatory response to wounding IMP
IMP: 通过突变表型推断
17015789 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
17230638 MGI
involved in negative regulation of ossification IMP
IMP: 通过突变表型推断
20200993 MGI
involved in oogenesis IMP
IMP: 通过突变表型推断
17121547 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
10096022 MGI
involved in positive regulation of T cell differentiation IMP
IMP: 通过突变表型推断
28183532 MGI
involved in positive regulation of artery morphogenesis IMP
IMP: 通过突变表型推断
29233575 MGI
involved in positive regulation of cartilage development IMP
IMP: 通过突变表型推断
25551381 MGI
involved in positive regulation of hepatocyte proliferation IMP
IMP: 通过突变表型推断
15482347 MGI
involved in positive regulation of inflammatory response to wounding IMP
IMP: 通过突变表型推断
24458438 MGI
involved in positive regulation of leukocyte adhesion to vascular endothelial cell IMP
IMP: 通过突变表型推断
24458438 MGI
involved in positive regulation of leukocyte chemotaxis IMP
IMP: 通过突变表型推断
15482347 MGI
involved in positive regulation of macrophage chemotaxis IMP
IMP: 通过突变表型推断
10683378 MGI
involved in positive regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
17230638 MGI
involved in positive regulation of neutrophil chemotaxis IMP
IMP: 通过突变表型推断
15509530 MGI
involved in positive regulation of neutrophil extravasation IMP
IMP: 通过突变表型推断
24458438 MGI
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
16901907 MGI
involved in positive regulation of vascular endothelial cell proliferation IMP
IMP: 通过突变表型推断
29233575 MGI
involved in regulation of behavior IMP
IMP: 通过突变表型推断
10096022 MGI
involved in regulation of bone remodeling IMP
IMP: 通过突变表型推断
21185956 MGI
involved in regulation of chondrocyte differentiation IMP
IMP: 通过突变表型推断
25551381 MGI
involved in response to auditory stimulus IMP
IMP: 通过突变表型推断
16619002 MGI
involved in response to wounding IDA
IDA: 通过直接分析推断
10683378 MGI
involved in short-term memory IMP
IMP: 通过突变表型推断
10096022 MGI
involved in tissue regeneration IMP
IMP: 通过突变表型推断
15482347 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

midkine

retanoic acid-responsive protein

retinoic acid-induced differentiation factor

retinoic acid-responsive protein

重组 Mdk 蛋白

目录号 产品名 蛋白编号 纯度
HY-P79419 Midkine Protein, Mouse P12025 (K23-D140) ≥95%
HY-P700223AF Animal-Free Midkine Protein, Mouse (His) P12025 (K23-D140) ≥95%
HY-P701025 MDK/Midkine Protein, Mouse (His) P12025 (K23-D140) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-110171 iMDK Inhibitor 99.35% 否
HY-110171A iMDK quarterhydrate Inhibitor 99.34% 否
HY-18633 MDK83190 Activator 98.40% 否
HY-119467 MDK0734 / 否
HY-RS08262 MDK Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mdk NCBI NCBI:4192
Rattus norvegicus Mdk NCBI NCBI:81517
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