Mfge8 - milk fat globule EGF and factor V/VIII domain containing Gene

种属: Mus musculus

同用名: P47; MP47; Mfgm; SED1; MFG-E8; lactadherin

关于 Mfge8

功能概要

Enables Integrin binding activity; phosphatidylethanolamine binding activity; and phosphatidylserine binding activity. Involved in apoptotic cell clearance. Acts upstream of or within phagocytosis, engulfment; phagocytosis, recognition; and positive regulation of phagocytosis. Located in external side of plasma membrane and extracellular space. Is extrinsic component of plasma membrane. Is expressed in several structures, including alimentary system; cap mesenchyme; central nervous system; reproductive system; and sensory organ. Human ortholog(s) of this gene implicated in temporal arteritis. Orthologous to human MFGE8 (milk fat globule EGF and factor V/VIII domain containing). [provided by Alliance of Genome Resources, Apr 2022]