2. Gene
  3. Mme - membrane metallo endopeptidase Gene

Mme - membrane metallo endopeptidase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: NEP; SFE; CD10; CALLA; 6030454K05Rik

基因 ID: 17380 | 基因类型: protein coding

关于 Mme

功能概要

Enables peptidase activity. Involved in amyloid-beta clearance; positive regulation of long-term synaptic potentiation; and sensory perception of pain. Acts upstream of or within amyloid-beta metabolic process. Located in several cellular components, including dendrite; neuron projection terminus; and synaptic vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and mammary gland. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Orthologous to human MME (membrane metalloendopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

Mme 基因产物(4)

mRNA Protein Name
NM_001289462.1 NP_001276391.1 neprilysin
NM_001289463.1 NP_001276392.1 neprilysin
NM_001357335.1 NP_001344264.1 neprilysin
NM_008604.4 NP_032630.2 neprilysin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables peptidase activity IDA
IDA: 通过直接分析推断
15944124 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amyloid-beta clearance IGI
IGI: 通过遗传相互作用推断
16636059 MGI
acts upstream of or within amyloid-beta metabolic process IDA
IDA: 通过直接分析推断
12074840 MGI
involved in positive regulation of long-term synaptic potentiation IGI
IGI: 通过遗传相互作用推断
16636059 MGI
involved in sensory perception of pain IMP
IMP: 通过突变表型推断
9751784 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
12074840 MGI
located in dendrite IDA
IDA: 通过直接分析推断
12074840 MGI
located in membrane IDA
IDA: 通过直接分析推断
15944124 MGI
located in neuron projection terminus IDA
IDA: 通过直接分析推断
12074840 MGI
located in synapse IDA
IDA: 通过直接分析推断
12074840 MGI
located in synaptic vesicle IDA
IDA: 通过直接分析推断
12074840 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neprilysin

atriopeptidase

common acute lymphoblastic leukemia antigen

enkephalinase

neutral endopeptidase 24.11

skin fibroblast elastase

重组 Mme 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72878 MME Protein, Mouse (HEK293, His) Q61391/NP_032630.2 (Y52-W750) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08513 MME Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-165037 1,2-Dimyristoyl-3-eicosapentaenoyl-rac-glycerol / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mme NCBI NCBI:4311
Canis familiaris Mme NCBI NCBI:477120
Macaca fascicularis Mme NCBI NCBI:101925772
Rattus norvegicus Mme NCBI NCBI:24590
Macaca mulatta Mme NCBI NCBI:707667
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