2. Gene
  3. Mme - membrane metallo-endopeptidase Gene

Mme - membrane metallo-endopeptidase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Nep; SFE; CD10

基因 ID: 24590 | 基因类型: protein coding

关于 Mme

功能概要

Enables oligopeptidase activity and peptide binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; animal organ development; and proteolysis. Located in plasma membrane. Used to study diarrhea and hypertension. Biomarker of Alzheimer's disease; congestive heart failure; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Orthologous to human MME (membrane metalloendopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

Mme 基因产物(1)

mRNA Protein Name
NM_012608.2 NP_036740.1 neprilysin
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables oligopeptidase activity IDA
IDA: 通过直接分析推断
3522576 RGD
enables peptide binding IDA
IDA: 通过直接分析推断
15308303 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amyloid-beta clearance IDA
IDA: 通过直接分析推断
19406747 RGD
involved in amyloid-beta clearance by cellular catabolic process IMP
IMP: 通过突变表型推断
18941241 RGD
involved in kidney development IEP
IEP: 通过表达模式推断
1547865 RGD
involved in lung development IEP
IEP: 通过表达模式推断
1547865 RGD
involved in peptide metabolic process IMP
IMP: 通过突变表型推断
10642323 RGD
involved in placenta development IEP
IEP: 通过表达模式推断
1547865 RGD
involved in protein catabolic process IDA
IDA: 通过直接分析推断
15308303 RGD
involved in response to estrogen IDA
IDA: 通过直接分析推断
15308303 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neprilysin

atriopeptidase

enkephalinase

membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase)

neutral endopeptidase 24.11

skin fibroblast elastase

重组 Mme 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73746 Neprilysin/CD10 Protein, Rat (HEK293, His) P07861 (Y52-W750) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08513 MME Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-165037 1,2-Dimyristoyl-3-eicosapentaenoyl-rac-glycerol / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mme NCBI NCBI:4311
Canis familiaris Mme NCBI NCBI:477120
Macaca fascicularis Mme NCBI NCBI:101925772
Mus musculus Mme NCBI NCBI:17380
Macaca mulatta Mme NCBI NCBI:707667
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