2. Gene
  3. Mmp14 - matrix metallopeptidase 14 (membrane-inserted) Gene

Mmp14 - matrix metallopeptidase 14 (membrane-inserted) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：基质金属肽酶 14 (膜插入)

种属: Mus musculus

同用名: sabe; MMP-X1; MT1-MMP; MT-MMP-1

基因 ID: 17387 | 基因类型: protein coding

关于 Mmp14

Chromosome 14: 54,669,069-54,682,821 forward strand.GRCm39:CM001007.3

This gene has 7 transcripts (splice variants), 272 orthologues, 23 paralogues and is associated with 113 phenotypes. Broad expression in ovary adult (RPKM 116.4), limb E14.5 (RPKM 1.7) and 24 other tissues.

功能概要

该基因编码细胞外基质降解酶基质金属蛋白酶家族的一个成员，这些酶参与组织重塑、伤口修复、动脉粥样硬化进展和肿瘤侵袭。编码的前原蛋白经过蛋白水解加工，产生成熟的锌依赖性内肽酶。缺乏编码蛋白的小鼠表现出颅面畸形、关节炎、骨质减少、侏儒症和软组织纤维化。 [RefSeq 提供，2016 年 2 月]

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme. Mice lacking the encoded protein exhibit craniofacial dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft tissues. [provided by RefSeq, Feb 2016]

Mmp14 基因产物(1)

mRNA Protein Name
NM_008608.4 NP_032634.3 matrix metalloproteinase-14 preproprotein
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables metalloendopeptidase activity IDA
IDA: 通过直接分析推断
21572390 MGI
enables metalloendopeptidase activity IMP
IMP: 通过突变表型推断
10737763 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within bone development IGI
IGI: 通过遗传相互作用推断
18022611 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IMP
IMP: 通过突变表型推断
15572153 MGI
acts upstream of or within cell migration IMP
IMP: 通过突变表型推断
15572153 MGI
acts upstream of or within chondrocyte proliferation IGI
IGI: 通过遗传相互作用推断
18022611 MGI
acts upstream of or within collagen catabolic process IGI
IGI: 通过遗传相互作用推断
18022611 MGI
acts upstream of or within craniofacial suture morphogenesis IGI
IGI: 通过遗传相互作用推断
18022611 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IGI
IGI: 通过遗传相互作用推断
18022611 MGI
acts upstream of or within endochondral ossification IGI
IGI: 通过遗传相互作用推断
18022611 MGI
acts upstream of or within head development IMP
IMP: 通过突变表型推断
26234751 MGI
acts upstream of or within lung development IMP
IMP: 通过突变表型推断
15572153 MGI
involved in negative regulation of Notch signaling pathway IMP
IMP: 通过突变表型推断
21572390 MGI
acts upstream of or within ossification IGI
IGI: 通过遗传相互作用推断
18022611 MGI
involved in positive regulation of B cell differentiation IMP
IMP: 通过突变表型推断
21572390 MGI
involved in positive regulation of macrophage migration IMP
IMP: 通过突变表型推断
24990232 MGI
involved in positive regulation of myotube differentiation IMP
IMP: 通过突变表型推断
21572390 MGI
involved in skeletal system development IMP
IMP: 通过突变表型推断
10737763 MGI
acts upstream of or within zymogen activation IMP
IMP: 通过突变表型推断
15572153 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mmp14 蛋白结构

PG_binding_1

PG_binding_1: pfam01471 (35 - 87)

Peptidase_M10

Peptidase_M10: pfam00413 (117 - 283)

HX

HX: cd00094 (315 - 507)

DUF3377

DUF3377: cl13321 (559 - 581)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 582 a.a.
蛋白主名 其他名称

matrix metalloproteinase-14

Membrane type 1-MMP

matrix metalloproteinase 14 (membrane-inserted)

membrane-type-1 matrix metalloproteinase

type 1 matrix metalloprotease 14

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-12169 Marimastat Inhibitor ≥98.0% Phase 3
Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15827 NSC 405020 Inhibitor 99.67% 否
HY-110397 KP-457 Inhibitor 99.18% 否
HY-107394 UK 356618 Inhibitor 98.91% 否
HY-107639 UK-370106 Inhibitor ≥99.0% 否
HY-124373 ND-336 Inhibitor 95.4% 否
HY-P3120 Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 96.30% 否
HY-110397G KP-457 (GMP) Inhibitor / 否
HY-114785 BPHA Inhibitor / 否
HY-124373A (R)-ND-336 Inhibitor / 否
HY-162038 RXP03 Inhibitor / 否
HY-E70290 N-Acetylgalactosaminyltransferase 1 Agonist / 否
HY-RS08528 MMP14 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08529 Mmp14 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08530 Mmp14 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mmp14 NCBI NCBI:4323
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