Mpl - myeloproliferative leukemia virus oncogene Gene

中文名称：骨髓增生性白血病病毒致癌基因

种属: Mus musculus

同用名: CD110; TPO-R; c-mpl; hlb219

关于 Mpl

功能概要

预测该基因编码的蛋白编码的蛋白可启动促血小板生成素受体活性。参与血小板生成素介导的信号通路。作用于多个过程的上游或内部，包括造血作用；基因表达的调节；和干细胞分裂的调节。预计位于多个细胞成分中，包括高尔基体；神经细胞体；和核膜。以多种结构表达，包括大脑；淋巴系统； splanchnopleure 衍生的间充质；生殖系统;和脊髓。用于研究先天性无巨核细胞性血小板减少症。该基因的人类直系同源物与先天性无巨核细胞性血小板减少症有关；原发性血小板增多症;骨髓纤维化;血小板减少症;和血小板增多症。与人类 MPL（MPL 原癌基因，血小板生成素受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Thrombopoietin Receptor activity. Involved in thrombopoietin-mediated signaling pathway. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of stem cell division. Predicted to be located in several cellular components, including Golgi apparatus; neuronal cell body; and nuclear membrane. Is expressed in several structures, including brain; hemolymphoid system; mesenchyme derived from splanchnopleure; reproductive system; and spinal cord. Used to study congenital amegakaryocytic thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, Thrombopoietin Receptor). [provided by Alliance of Genome Resources, Apr 2022]