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  3. Mpl - MPL proto-oncogene, thrombopoietin receptor Gene

Mpl - MPL proto-oncogene, thrombopoietin receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：MPL 原癌基因，血小板生成素受体

种属: Rattus norvegicus

基因 ID: 366455 | 基因类型: protein coding

关于 Mpl

Primary_assembly 5: 131,973,895-131,986,797 reverse strand.mRatBN7.2:CM026978.1

This gene has 2 transcripts (splice variants), 186 orthologues, 7 paralogues and is associated with 19 phenotypes. Biased expression in Spleen (RPKM 1.6), Testes (RPKM 2.4) and 3 other tissues.

功能概要

预测该基因编码的蛋白编码的蛋白可启动促血小板生成素受体活性。涉及多个过程，包括骨髓细胞稳态；血小板聚集;和血小板形成的正调节。位于多个细胞成分中，包括细胞表面；神经元投射；和神经细胞体。用于研究骨髓纤维化。血小板减少症的生物标志物。该基因的人类直系同源物与先天性无巨核细胞性血小板减少症有关；原发性血小板增多症;骨髓纤维化;血小板减少症;和血小板增多症。与人类 MPL（MPL 原癌基因，血小板生成素受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Thrombopoietin Receptor activity. Involved in several processes, including myeloid cell homeostasis; platelet aggregation; and positive regulation of platelet formation. Located in several cellular components, including cell surface; neuron projection; and neuronal cell body. Used to study myelofibrosis. Biomarker of thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, Thrombopoietin Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Mpl 基因产物(7)

mRNA Protein Name
XM_345572.10 XP_345573.5 thrombopoietin receptor isoform X4
XM_017593806.2 XP_017449295.1 thrombopoietin receptor isoform X3
XM_017593805.2 XP_017449294.1 thrombopoietin receptor isoform X2
XM_017593804.2 XP_017449293.1 thrombopoietin receptor isoform X1
XM_006238749.4 XP_006238811.1 thrombopoietin receptor isoform X7
XM_039111191.1 XP_038967119.1 thrombopoietin receptor isoform X5
XM_039111192.1 XP_038967120.1 thrombopoietin receptor isoform X6
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in basophil homeostasis IMP
IMP: 通过突变表型推断
10606160 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
15642952 RGD
involved in eosinophil homeostasis IMP
IMP: 通过突变表型推断
10606160 RGD
involved in monocyte homeostasis IMP
IMP: 通过突变表型推断
10606160 RGD
involved in neutrophil homeostasis IMP
IMP: 通过突变表型推断
10606160 RGD
involved in positive regulation of lymphocyte proliferation IMP
IMP: 通过突变表型推断
10606160 RGD
involved in positive regulation of platelet formation IMP
IMP: 通过突变表型推断
10606160 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
20467749 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
15642952 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mpl 蛋白结构

FN3

FN3: cl21522 (120 - 218)

FN3

FN3: cd00063 (496 - 585)

  • 0
  • 200
  • 400
  • 600
  • 735 a.a.
蛋白主名 其他名称

thrombopoietin receptor

myeloproliferative leukemia virus oncogene

重组 Mpl 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74243 C-MPL Protein, Rat (sf9, His) A0A1W2Q6N1/XP_001072502.1 (Q22-A500) ≥95%
HY-P74244 C-MPL Protein, Rat (HEK293, Fc) A0A1W2Q6N1/XP_001072502.1 (Q22-A500) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148748 Butyzamide Activator 99.62% 否
HY-112486 TA-316 98.04% 否
HY-10219GL Rapamycin (GMP Like) Inhibitor 98.8% 否
HY-112486G TA-316 (GMP) Agonist / 否
HY-144002 RIBI-529 / 否
HY-159671 3D-Monophosphoryl Lipid (14) / 否
HY-159672 3D-Monophosphoryl Lipid (12,16) / 否
HY-NP074 Maclura Pomifera Lectin / 否
HY-RS08616 MPL Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08617 Mpl Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08618 Mpl Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-159671A 3D-Monophosphoryl Lipid (14) triethylamine Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mpl NCBI NCBI:4352
Canis familiaris Mpl NCBI NCBI:610801
Macaca fascicularis Mpl NCBI NCBI:101864977
Mus musculus Mpl NCBI NCBI:17480
Susscrofa domestica Mpl NCBI
Macaca mulatta Mpl NCBI NCBI:723813
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