2. Gene
  3. Sik1 - salt inducible kinase 1 Gene

Sik1 - salt inducible kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：盐诱导激酶 1

种属: Mus musculus

同用名: Msk; Sik; Sik-1; Hrt-20; Snf1lk

基因 ID: 17691 | 基因类型: protein coding

关于 Sik1

Chromosome 17: 32,063,224-32,074,778 reverse strand.GRCm39:CM001010.3

This gene has 4 transcripts (splice variants), 236 orthologues, 19 paralogues and is associated with 18 phenotypes. Ubiquitous expression in lung adult (RPKM 31.), spleen adult (RPKM 26.) and 27 other tissues.

功能概要

该基因编码的蛋白可启动多项功能，包括 ATP 绑定活动； cAMP反应元件结合蛋白结合活性；和酶结合活性。涉及多个过程，包括失巢凋亡；光周期对生物钟的影响；和调节细胞生物合成过程。在细胞分化调节的上游或调节内起作用。位于细胞质和细胞核中。以多种结构表达，包括消化系统；脑;泌尿生殖系统；心;和感觉器官。该基因的人类直向同源基因与发育和癫痫性脑病 30 相关。与人类 SIK1（盐诱导激酶 1）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; cAMP response element binding protein binding activity; and Enzyme binding activity. Involved in several processes, including anoikis; entrainment of circadian clock by photoperiod; and regulation of cellular biosynthetic process. Acts upstream of or within regulation of cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 30. Orthologous to human SIK1 (salt inducible kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sik1 基因产物(1)

mRNA Protein Name
NM_010831.3 NP_034961.2 serine/threonine-protein kinase SIK1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
15177563 MGI
enables cAMP response element binding protein binding IDA
IDA: 通过直接分析推断
12200423 MGI
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
17468767 MGI
enables magnesium ion binding IDA
IDA: 通过直接分析推断
15177563 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
19244231 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
12200423 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
12624099 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in anoikis IMP
IMP: 通过突变表型推断
19622832 MGI
involved in cardiac muscle cell differentiation IMP
IMP: 通过突变表型推断
20140255 MGI
involved in entrainment of circadian clock by photoperiod IMP
IMP: 通过突变表型推断
23993098 MGI
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
15177563 MGI
involved in negative regulation of CREB transcription factor activity IDA
IDA: 通过直接分析推断
12200423 MGI
involved in negative regulation of CREB transcription factor activity IMP
IMP: 通过突变表型推断
23993098 MGI
involved in negative regulation of gluconeogenesis IDA
IDA: 通过直接分析推断
16148943 MGI
involved in negative regulation of triglyceride biosynthetic process IDA
IDA: 通过直接分析推断
19244231 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
12624099 MGI
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
15177563 MGI
involved in regulation of cell differentiation IEP
IEP: 通过表达模式推断
15177563 MGI
involved in regulation of mitotic cell cycle IDA
IDA: 通过直接分析推断
15177563 MGI
involved in regulation of myotube differentiation IDA
IDA: 通过直接分析推断
17468767 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12200423 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12200423 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Sik1 蛋白结构

STKc_SIK

STKc_SIK: cd14071 (25 - 277)

UBA_SIK1

UBA_SIK1: cd14408 (299 - 348)

  • 0
  • 200
  • 400
  • 600
  • 779 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase SIK1

Probable serine/threonine protein kinase SNF1LK (HRT-20) (Myocardial SNF1-like kinase)

SNF1-like kinase

myocardial SNF1-like kinase

salt-inducible protein kinase 1

serine/threonine-protein kinase SNF1-like kinase 1

serine/threonine-protein kinase SNF1LK

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15776 HG-9-91-01 Inhibitor 99.77% 否
HY-101147 YKL-05-099 Inhibitor 99.76% 否
HY-120877 MRT199665 Inhibitor 99.74% 否
HY-120856 ARN-3236 Inhibitor 98.60% 否
HY-157442 GLPG3312 Inhibitor 98.25% 否
HY-120056 YKL-06-061 Inhibitor 99.66% 否
HY-139253 MRIA9 Inhibitor 98.80% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sik1 NCBI NCBI:150094
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