2. Gene
  3. DOK1 - docking protein 1 Gene

DOK1 - docking protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：对接蛋白 1

种属: Homo sapiens

同用名: pp62; P62DOK

基因 ID: 1796 | 基因类型: protein coding

关于 DOK1

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,549,105-74,557,551 (from NCBI)

This gene has 13 transcripts (splice variants), 196 orthologues and 7 paralogues. Ubiquitous expression in fat (RPKM 6.6), spleen (RPKM 6.2) and 25 other tissues.

功能概要

由该基因编码的蛋白质是受体酪氨酸激酶下游信号转导通路的一部分。编码的蛋白质是一种支架蛋白，有助于形成多蛋白信号复合物组装的平台。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2016 年 1 月]

The protein encoded by this gene is part of a signal transduction pathway downstream of Receptor Tyrosine Kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

DOK1 基因产物(6)

mRNA Protein Name
NM_001197260.2 NP_001184189.1 docking protein 1 isoform b
NM_001318866.2 NP_001305795.1 docking protein 1 isoform b
NM_001318867.2 NP_001305796.1 docking protein 1 isoform c
NM_001318868.2 NP_001305797.1 docking protein 1 isoform d
NM_001318869.2 NP_001305798.1 docking protein 1 isoform e
NM_001381.5 NP_001372.1 docking protein 1 isoform a
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16273093 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
23822091 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DOK1 蛋白结构

IRS

IRS: PTB domain (IRS-1 type) (152 - 253)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 481 a.a.
蛋白主名 其他名称

docking protein 1

Downstream of tyrosine kinase 1

DOK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
DOK1 Q99704 ORF Human immunodeficiency virus Q9Q2G4
Pull Down
22190034
种属内
DOK1 Q99704 ERBB2 Homo sapiens P04626
Protein Array
16273093
种属内
DOK1 Q99704 SRMS Homo sapiens Q9H3Y6
Anti Bait CoIP
23822091
种属内
DOK1 Q99704 SRMS Homo sapiens Q9H3Y6
Protein Kinase Assay
23822091
种属内
DOK1 Q99704 SRMS Homo sapiens Q9H3Y6
Anti Tag CoIP
23822091
种属间: 跨种属相互作用 种属内: 同种属相互作用

DOK1 抗体

目录号 产品名 应用 反应物种
HY-P83123 DOK1 Antibody (YA2868) WB, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Myopia 28, Autosomal Recessive

MYP28
Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03933 DOK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus DOK1 MGD MGI:893587
Bos taurus DOK1 VGNC VGNC:28165
Canis familiaris DOK1 VGNC VGNC:40055
Rattus norvegicus DOK1 RGD RGD:1309499
Macaca mulatta DOK1 VGNC VGNC:71968
Felis catus DOK1 VGNC VGNC:61580
Macaca fascicularis DOK1 NCBI NCBI:102127645
Others DOK1 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z