Nfkb1 - nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Gene

中文名称：B 细胞 1 ，p105 中 κ轻多肽基因增强子的核因子

种属: Mus musculus

同用名: p50; p105; NF-KB1; p50/p105; NF-kappaB; NF-kappaB1

关于 Nfkb1

功能概要

该基因编码的蛋白可启动 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性；染色质结合活性；和相同的蛋白质结合活性。参与JNK级联；细胞对病毒的反应；和细胞因子产生的负调节。在几个过程的上游或内部起作用，包括对 dsRNA 的细胞反应；细胞对肿瘤坏死因子的反应；和基因表达的调控。位于细胞质和细胞核中。以多种结构表达，包括消化系统；泌尿生殖系统；神经系统;鼻子;和呼吸系统。该基因的人类直系同源物与多种疾病有关，包括癌（多种）；常见变异型免疫缺陷；黑色素瘤;前列腺癌;和热带痉挛性轻瘫。与人类 NFKB1（核因子 kappa B 亚基 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin binding activity; and identical protein binding activity. Involved in JNK cascade; cellular response to virus; and negative regulation of cytokine production. Acts upstream of or within several processes, including cellular response to dsRNA; cellular response to tumor necrosis factor; and regulation of gene expression. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Apr 2022]