Nodal - nodal Gene

种属: Mus musculus

同用名: Tg.413d

基因 ID: 18119 | 基因类型: protein coding

关于 Nodal

功能概要

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. Homozygous knockout mice for this gene exhibit early embryonic lethality, while expression of a hypomorphic allele results in defects in anteroposterior and left-right patterning. [provided by RefSeq, Aug 2016]

Nodal 基因产物(1)

mRNA	Protein	Name
NM_013611.5	NP_038639.2	nodal preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	12052855	MGI
enables receptor ligand activity	IDA IDA: 通过直接分析推断	12052855	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within anatomical structure formation involved in morphogenesis	IMP IMP: 通过突变表型推断	7924997	MGI
acts upstream of or within anterior/posterior axis specification	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: 通过遗传相互作用推断	16496285	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within axial mesodermal cell fate specification	IMP IMP: 通过突变表型推断	14511481	MGI
acts upstream of or within brain development	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of cell differentiation	IDA IDA: 通过直接分析推断	11456449	MGI
acts upstream of or within cell fate commitment	IMP IMP: 通过突变表型推断	12842913	MGI
acts upstream of or within cell migration	IMP IMP: 通过突变表型推断	15302604	MGI
acts upstream of or within cell migration involved in gastrulation	IDA IDA: 通过直接分析推断	15004567	MGI
acts upstream of cell population proliferation	IMP IMP: 通过突变表型推断	15004567	MGI
involved in determination of left/right asymmetry in lateral mesoderm	IMP IMP: 通过突变表型推断	17507406	MGI
acts upstream of or within determination of left/right symmetry	IDA IDA: 通过直接分析推断	12642485	MGI
acts upstream of or within determination of left/right symmetry	IGI IGI: 通过遗传相互作用推断	15466485	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within digestive system development	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within digestive tract morphogenesis	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within embryonic heart tube development	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within embryonic pattern specification	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within embryonic placenta development	IMP IMP: 通过突变表型推断	11456449	MGI
acts upstream of or within embryonic process involved in female pregnancy	IMP IMP: 通过突变表型推断	11456449	MGI
acts upstream of or within endoderm development	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification	IMP IMP: 通过突变表型推断	14511481	MGI
acts upstream of or within floor plate morphogenesis	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within formation of anatomical boundary	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within gastrulation	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within gastrulation with mouth forming second	IMP IMP: 通过突变表型推断	14607953	MGI
acts upstream of germ cell development	IMP IMP: 通过突变表型推断	23034635	MGI
acts upstream of or within heart development	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within heart looping	IGI IGI: 通过遗传相互作用推断	16496285	MGI
acts upstream of or within in utero embryonic development	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within inhibition of neuroepithelial cell differentiation	IMP IMP: 通过突变表型推断	16678814	MGI
acts upstream of or within left lung morphogenesis	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within liver development	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within lung development	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within maternal placenta development	IMP IMP: 通过突变表型推断	22378764	MGI
acts upstream of or within maternal process involved in parturition	IMP IMP: 通过突变表型推断	22378764	MGI
acts upstream of or within mesendoderm development	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within mesoderm formation	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within negative regulation of cell development	IMP IMP: 通过突变表型推断	23034635	MGI
acts upstream of or within negative regulation of cell differentiation	IDA IDA: 通过直接分析推断	11456449	MGI
acts upstream of or within negative regulation of reproductive process	IMP IMP: 通过突变表型推断	23034635	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	11456449	MGI
acts upstream of or within nervous system development	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within neural fold formation	IMP IMP: 通过突变表型推断	11311163	MGI
involved in nodal signaling pathway	IMP IMP: 通过突变表型推断	12052855	MGI
acts upstream of or within polarity specification of proximal/distal axis	IMP IMP: 通过突变表型推断	14511481	MGI
involved in positive regulation of angiogenesis	IMP IMP: 通过突变表型推断	21116837	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	15004567	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17507406	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	17568773	MGI
acts upstream of or within primitive streak formation	IGI IGI: 通过遗传相互作用推断	21445260	MGI
acts upstream of or within regulation of gastrulation	IGI IGI: 通过遗传相互作用推断	20040491	MGI
acts upstream of or within regulation of signal transduction	IDA IDA: 通过直接分析推断	17936261	MGI
acts upstream of or within somatic stem cell population maintenance	IGI IGI: 通过遗传相互作用推断	15505202	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: 通过突变表型推断	16678814	MGI
acts upstream of or within stem cell population maintenance	IGI IGI: 通过遗传相互作用推断	15505202	MGI
acts upstream of or within tissue morphogenesis	IMP IMP: 通过突变表型推断	11311163	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IMP IMP: 通过突变表型推断	14511481	MGI
acts upstream of or within trophectodermal cell differentiation	IDA IDA: 通过直接分析推断	11456449	MGI
acts upstream of or within trophectodermal cellular morphogenesis	IMP IMP: 通过突变表型推断	11456449	MGI
acts upstream of or within vasculature development	IMP IMP: 通过突变表型推断	11311163	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular region	IDA IDA: 通过直接分析推断	12052855	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

nodal

重组 Nodal 蛋白

目录号	产品名	蛋白编号	纯度
HY-P79080	Nodal Protein, Mouse	P43021 (H245-L354)	≥95%

目录号	产品名	作用方式	纯度	是否罕见病
HY-A0016	Dronedarone		99.93%	否
HY-17611	Etripamil	Antagonist	98.80%	否

目录号	产品名	作用方式	纯度	Phase
HY-106577	Cibenzoline		99.96%	Phase 4

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-10432	A 83-01	Inhibitor	99.41%	否
HY-10432R	A 83-01 (Standard)	Inhibitor	/	否
HY-RS09409	NODAL Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-123196	CVT-2759	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Nodal	NCBI	NCBI:4838

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Nodal - nodal Gene

关于 Nodal

功能概要

Nodal 基因产物(1)

重组 Nodal 蛋白

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Nodal - nodal Gene

关于 Nodal

功能概要

Nodal 基因产物(1)

重组 Nodal 蛋白

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z