1. Gene
  2. Npy5r - neuropeptide Y receptor Y5 Gene

Npy5r - neuropeptide Y receptor Y5 Gene

中文名称:神经肽 Y 受体 Y5

种属: Mus musculus

同用名: Y5R; NPY5-R; NPYY5-R

基因 ID: 18168 | 基因类型: protein coding

关于 Npy5r

Chromosome 8: 67,132,617-67,140,780 reverse strand.GRCm39:CM001001.3

This gene has 3 transcripts (splice variants), 137 orthologues, 55 paralogues and is associated with 16 phenotypes. Biased expression in cortex adult (RPKM 1.1), frontal lobe adult (RPKM 1.) and 5 other tissues.

功能概要

该基因编码的蛋白可启动胰多肽受体活性和肽YY受体活性。在化学突触传递的上游或内部起作用。位于膜和神经元投射处。在中枢神经系统和视网膜中表达。该基因的人类直系同源物与脂质代谢紊乱和肥胖有关。与人 NPY5R(神经肽 Y 受体 Y5)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Acts upstream of or within chemical synaptic transmission. Located in membrane and neuron projection. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (Neuropeptide Y Receptor Y5). [provided by Alliance of Genome Resources, Apr 2022]

Npy5r 基因产物(3)

mRNA Protein Name
NM_001358957.1 NP_001345886.1 neuropeptide Y receptor type 5
NM_001358958.1 NP_001345887.1 neuropeptide Y receptor type 5
NM_016708.3 NP_057917.2 neuropeptide Y receptor type 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables neuropeptide Y receptor activity IDA
IDA: 通过直接分析推断
9802393 MGI
enables pancreatic polypeptide receptor activity IDA
IDA: 通过直接分析推断
9802393 MGI
enables peptide YY receptor activity IDA
IDA: 通过直接分析推断
9802393 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within chemical synaptic transmission IMP
IMP: 通过突变表型推断
10557353 MGI
involved in synaptic signaling via neuropeptide EXP
EXP: 通过实验结果推断
22190627 MGI
involved in synaptic signaling via neuropeptide IDA
IDA: 通过直接分析推断
22190627 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse EXP
EXP: 通过实验结果推断
22190627 MGI
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
22190627 MGI
located in membrane IDA
IDA: 通过直接分析推断
9802393 MGI
located in neuron projection IDA
IDA: 通过直接分析推断
24316073 MGI
is active in presynapse IDA
IDA: 通过直接分析推断
22190627 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Npy5r 蛋白结构

7tmA_NPY5R

7tmA_NPY5R: cd15398 (62 - 455)

7tmA_NPY5R

7tmA_NPY5R: cd15398 (63 - 89)

7tmA_NPY5R

7tmA_NPY5R: cd15398 (96 - 121)

7tmA_NPY5R

7tmA_NPY5R: cd15398 (134 - 164)

7tmA_NPY5R

7tmA_NPY5R: cd15398 (175 - 196)

7tmA_NPY5R

7tmA_NPY5R: cd15398 (228 - 257)

7tmA_NPY5R

7tmA_NPY5R: cd15398 (380 - 410)

7tmA_NPY5R

7tmA_NPY5R: cd15398 (423 - 448)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 466 a.a.
蛋白主名 其他名称

neuropeptide Y receptor type 5

NPY-Y5 receptor

Y5 receptor

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Npy5r NCBI NCBI:4889