1. Gene
  2. Ntrk1 - neurotrophic tyrosine kinase, receptor, type 1 Gene

Ntrk1 - neurotrophic tyrosine kinase, receptor, type 1 Gene

中文名称:神经营养性酪氨酸激酶,受体,1 型

种属: Mus musculus

同用名: Tkr; trk; TrkA

基因 ID: 18211 | 基因类型: protein coding

关于 Ntrk1

Chromosome 3: 87,685,551-87,702,469 reverse strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 200 orthologues, 53 paralogues and is associated with 36 phenotypes. Biased expression in adrenal adult (RPKM 7.1), CNS E14 (RPKM 2.8) and 13 other tissues.

功能概要

预计该基因编码的蛋白具有多种功能,包括 GPI 相关肝配蛋白受体活性;神经生长因子结合活性;和神经生长因子受体活性。参与参与神经支配的轴突发生;神经元凋亡过程的负调控;和交感神经系统发育。在几个过程的上游或内部起作用,包括对福尔马林引起的疼痛的行为反应;神经生长因子信号通路;和神经系统发育。位于轴突;细胞表面;和核内体。以多种结构表达,包括鳃弓;性腺;神经系统;感觉器官;和泌尿生殖嵴。用于研究遗传性感觉神经病。该基因的人类直系同源物与阿尔茨海默病有关;遗传性感觉神经病; 4 型遗传性感觉神经病;和精神分裂症。与人类 NTRK1(神经营养受体酪氨酸激酶 1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable several functions, including GPI-linked Ephrin Receptor activity; nerve growth factor binding activity; and nerve growth factor receptor activity. Involved in axonogenesis involved in innervation; negative regulation of neuron apoptotic process; and sympathetic nervous system development. Acts upstream of or within several processes, including behavioral response to formalin induced pain; nerve growth factor signaling pathway; and nervous system development. Located in axon; cell surface; and endosome. Is expressed in several structures, including branchial arch; gonad; nervous system; sensory organ; and urogenital ridge. Used to study hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk1 基因产物(1)

mRNA Protein Name
NM_001033124.1 NP_001028296.1 high affinity nerve growth factor receptor precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16049186 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within B cell differentiation IMP
IMP: 通过突变表型推断
15459109 MGI
involved in axonogenesis involved in innervation IMP
IMP: 通过突变表型推断
8815902 MGI
acts upstream of or within behavioral response to formalin induced pain IMP
IMP: 通过突变表型推断
24760869 MGI
acts upstream of or within cellular response to nerve growth factor stimulus IDA
IDA: 通过直接分析推断
24760869 MGI
involved in circadian rhythm IEP
IEP: 通过表达模式推断
23785138 MGI
acts upstream of or within innervation IMP
IMP: 通过突变表型推断
24760869 MGI
acts upstream of or within mechanoreceptor differentiation IMP
IMP: 通过突变表型推断
15376326 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
11731452 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
8815902 MGI
acts upstream of or within nerve growth factor signaling pathway IDA
IDA: 通过直接分析推断
7854358 MGI
acts upstream of or within nerve growth factor signaling pathway IGI
IGI: 通过遗传相互作用推断
24270184 MGI
acts upstream of or within nervous system development IDA
IDA: 通过直接分析推断
12810599 MGI
acts upstream of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
11731452 MGI
acts upstream of or within positive regulation of synapse assembly IDA
IDA: 通过直接分析推断
24613359 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
11877420 MGI
involved in sympathetic nervous system development IMP
IMP: 通过突变表型推断
8815902 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
24270184 MGI
located in cell surface IDA
IDA: 通过直接分析推断
24760869 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
10207144 MGI
located in early endosome IDA
IDA: 通过直接分析推断
24270184 MGI
located in late endosome IDA
IDA: 通过直接分析推断
24760869 MGI
part of protein-containing complex IDA
IDA: 通过直接分析推断
27076424 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Ntrk1 蛋白结构

LRR_1

LRR_1: sd00031 (67 - 91)

LRR_8

LRR_8: pfam13855 (91 - 149)

LRR_1

LRR_1: sd00031 (92 - 115)

LRR_1

LRR_1: sd00031 (116 - 138)

LRR_1

LRR_1: sd00031 (139 - 151)

TPKR_C2

TPKR_C2: pfam16920 (150 - 193)

Ig

Ig: cl11960 (196 - 283)

Ig

Ig: cd00096 (212 - 216)

Ig

Ig: cd00096 (225 - 229)

Ig

Ig: cd00096 (248 - 252)

Ig

Ig: cd00096 (263 - 268)

Ig

Ig: cd00096 (276 - 279)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (286 - 292)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (286 - 381)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (294 - 297)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (300 - 308)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (311 - 318)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (321 - 324)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (329 - 335)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (343 - 351)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (359 - 367)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (370 - 378)

PKc_like

PKc_like: cl21453 (506 - 785)

  • 0
  • 200
  • 400
  • 600
  • 799 a.a.
蛋白主名 其他名称

high affinity nerve growth factor receptor

重组 Ntrk1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76115 TrkA Protein, Mouse (HEK293, Fc) Q3UFB7/NP_001028296.1 (A34-G420) ≥95%
HY-P76116 TrkA Protein, Mouse (HEK293, His) Q3UFB7/NP_001028296.1 (A34-G420) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ntrk1 NCBI NCBI:4914
Canis familiaris Ntrk1 NCBI NCBI:490404
Leporidae Ntrk1 NCBI
Rattus norvegicus Ntrk1 NCBI NCBI:59109