Ntrk1 - neurotrophic receptor tyrosine kinase 1 Gene

中文名称：神经营养 受体酪氨酸激酶 1

种属: Rattus norvegicus

同用名: Trk

关于 Ntrk1

功能概要

该基因编码的蛋白可启动多种功能，包括 GPI 相关肝配蛋白受体活性；神经生长因子结合活性；和神经营养蛋白 p75 受体结合活性。涉及多个过程，包括检测与疼痛感觉相关的刺激；神经系统发育；和程序性细胞死亡的调节。在细胞对生长因子刺激和蛋白质自磷酸化反应的上游或细胞反应中起作用。位于多个细胞成分中，包括树突；核内体；和神经细胞体。部分含蛋白质复合物。用于研究青光眼和肌筋膜疼痛综合征。多种疾病的生物标志物，包括结肠炎；糖尿病性神经病变；青光眼;牙周炎;和视网膜脱离。该基因的人类直系同源物与阿尔茨海默病有关；遗传性感觉神经病； 4 型遗传性感觉神经病；和精神分裂症。与人类 NTRK1（神经营养受体酪氨酸激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including GPI-linked Ephrin Receptor activity; nerve growth factor binding activity; and neurotrophin p75 receptor binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; nervous system development; and regulation of programmed cell death. Acts upstream of or within cellular response to growth factor stimulus and protein autophosphorylation. Located in several cellular components, including dendrite; endosome; and neuronal cell body. Part of protein-containing complex. Used to study glaucoma and myofascial pain syndrome. Biomarker of several diseases, including colitis; diabetic neuropathy; glaucoma; periodontitis; and retinal detachment. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]