DUSP8 - dual specificity phosphatase 8 Gene

中文名称：双特异性磷酸酶 8

种属: Homo sapiens

同用名: HB5; HVH8; HVH-5; C11orf81

关于 DUSP8

功能概要

该基因编码的蛋白质是双特异性蛋白磷酸酶亚家族的成员。这些磷酸酶通过使磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基去磷酸化来灭活它们的靶激酶。它们负向调节与细胞增殖和分化相关的丝裂原活化蛋白 (MAP) 激酶超家族成员 (MAPK/ERK、SAPK/JNK、p38) 。双特异性磷酸酶家族的不同成员对各种 MAP 激酶表现出不同的底物特异性、不同的组织分布和亚细胞定位，以及细胞外刺激表达的不同诱导模式。该基因产物使 SAPK/JNK 和 p38 失活，主要在成人大脑、心脏和骨骼肌中表达，位于细胞质中，并由神经生长因子和胰岛素诱导。 DUSP8 的无内含子假基因存在于染色体 10q11.2 上。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and Insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]