2. Gene
  3. Pde9a - phosphodiesterase 9A Gene

Pde9a - phosphodiesterase 9A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 9A

种属: Mus musculus

同用名: PDE9A1

基因 ID: 18585 | 基因类型: protein coding

关于 Pde9a

Chromosome 17: 31,605,184-31,695,284 forward strand.GRCm39:CM001010.3

This gene has 28 transcripts (splice variants), 192 orthologues, 20 paralogues and is associated with 1 phenotype. Broad expression in colon adult (RPKM 62.7), large intestine adult (RPKM 61.1) and 19 other tissues.

功能概要

该基因编码的蛋白可启动 3',5'-环状 GMP 磷酸二酯酶活性。参与 cGMP 分解代谢过程和心肌肥大的正调节。预计位于几种细胞成分中，包括核质；核周;和肌膜。以多种结构表达，包括消化系统；心血管系统;泌尿生殖系统；神经系统;和感觉器官。与人 PDE9A（磷酸二酯酶 9A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP catabolic process and positive regulation of cardiac muscle hypertrophy. Predicted to be located in several cellular components, including nucleoplasm; perikaryon; and sarcolemma. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human PDE9A (phosphodiesterase 9A). [provided by Alliance of Genome Resources, Apr 2022]

Pde9a 基因产物(7)

mRNA Protein Name
NM_001410690.1 NP_001397619.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 4
NM_001410691.1 NP_001397620.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 4
NM_001163748.2 NP_001157220.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 1
NM_008804.5 NP_032830.3 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 1
NM_001410687.1 NP_001397616.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 2
NM_001410688.1 NP_001397617.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 3
NM_001410689.1 NP_001397618.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 4
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
9624145 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cGMP catabolic process IDA
IDA: 通过直接分析推断
9624145 MGI
involved in cGMP catabolic process IMP
IMP: 通过突变表型推断
25799991 MGI
involved in positive regulation of cardiac muscle hypertrophy IMP
IMP: 通过突变表型推断
25799991 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pde9a 蛋白结构

PDEase_I

PDEase_I: pfam00233 (249 - 477)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 534 a.a.
蛋白主名 其他名称

high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-15441 Edelinontrine Inhibitor 99.85% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12788 PF-04449613 Inhibitor 99.83% 否
HY-104028 BAY 73-6691 Inhibitor 99.84% 否
HY-126137 PDE9-IN-1 Inhibitor 99.70% 否
HY-152106 BAY-7081 Inhibitor 98.00% 否
HY-12788A (S)-PF-04449613 Inhibitor 99.85% 否
HY-104028B (S)-BAY 73-6691 Control 99.51% 否
HY-RS10246 PDE9A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10247 Pde9a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10248 Pde9a Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pde9a NCBI NCBI:5152
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