1. Gene
  2. Pdgfb - platelet derived growth factor, B polypeptide Gene

Pdgfb - platelet derived growth factor, B polypeptide Gene

种属: Mus musculus

同用名: Sis; c-sis; PDGF-2; PDGF-B

基因 ID: 18591 | 基因类型: protein coding

关于 Pdgfb

功能概要

Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including metanephric glomerular mesangium development; paracrine signaling; and positive regulation of glomerular filtration. Acts upstream of or within several processes, including animal organ development; nervous system development; and regulation of cell migration. Predicted to be located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; female reproductive system; and nervous system. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue Cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B). [provided by Alliance of Genome Resources, Apr 2022]

Pdgfb 基因产物(3)

mRNA Protein Name
NM_001411619.1 NP_001398548.1 platelet-derived growth factor subunit B isoform 2
NM_001411620.1 NP_001398549.1 platelet-derived growth factor subunit B isoform 2
NM_011057.5 NP_035187.2 platelet-derived growth factor subunit B isoform 1 preproprotein
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within actin cytoskeleton organization IDA
IDA: 通过直接分析推断
12176888 MGI
acts upstream of or within actin cytoskeleton organization IGI
IGI: 通过遗传相互作用推断
16456542 MGI
involved in blood vessel development IEP
IEP: 通过表达模式推断
10375497 MGI
acts upstream of or within blood vessel morphogenesis IDA
IDA: 通过直接分析推断
15919073 MGI
acts upstream of or within blood vessel morphogenesis IGI
IGI: 通过遗传相互作用推断
15919073 MGI
acts upstream of or within branching involved in salivary gland morphogenesis IMP
IMP: 通过突变表型推断
18559345 MGI
acts upstream of cell migration IGI
IGI: 通过遗传相互作用推断
16644864 MGI
acts upstream of or within cell projection assembly IDA
IDA: 通过直接分析推断
12176888 MGI
involved in cellular response to platelet-derived growth factor stimulus IDA
IDA: 通过直接分析推断
28867608 MGI
involved in embryonic placenta development IMP
IMP: 通过突变表型推断
15084468 MGI
acts upstream of endothelial cell proliferation IGI
IGI: 通过遗传相互作用推断
16644864 MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis IMP
IMP: 通过突变表型推断
18559345 MGI
acts upstream of or within eye photoreceptor cell development IMP
IMP: 通过突变表型推断
25224828 MGI
acts upstream of fibroblast growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
18559345 MGI
acts upstream of or within fibroblast migration IDA
IDA: 通过直接分析推断
15183724 MGI
acts upstream of fibroblast migration IGI
IGI: 通过遗传相互作用推断
16456542 MGI
acts upstream of or within glial cell development IMP
IMP: 通过突变表型推断
25224828 MGI
involved in heart development IMP
IMP: 通过突变表型推断
15084468 MGI
involved in metanephric glomerular endothelium development IEP
IEP: 通过表达模式推断
9693135 MGI
involved in metanephric glomerular mesangial cell development IMP
IMP: 通过突变表型推断
15084468 MGI
involved in metanephric glomerular mesangial cell proliferation involved in metanephros development IMP
IMP: 通过突变表型推断
9693135 MGI
acts upstream of or within negative regulation of vascular associated smooth muscle cell migration IGI
IGI: 通过遗传相互作用推断
16644864 MGI
acts upstream of or within neuron remodeling IMP
IMP: 通过突变表型推断
25224828 MGI
involved in paracrine signaling IMP
IMP: 通过突变表型推断
15084468 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: 通过遗传相互作用推断
16456542 MGI
acts upstream of or within positive regulation of endothelial cell proliferation IGI
IGI: 通过遗传相互作用推断
16644864 MGI
acts upstream of or within positive regulation of fibroblast growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
18559345 MGI
acts upstream of or within positive regulation of fibroblast migration IGI
IGI: 通过遗传相互作用推断
16456542 MGI
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
28867608 MGI
involved in positive regulation of glomerular filtration IMP
IMP: 通过突变表型推断
15084468 MGI
acts upstream of or within positive regulation of mitotic cell cycle, embryonic IGI
IGI: 通过遗传相互作用推断
18827006 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: 通过遗传相互作用推断
16456542 MGI
involved in positive regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
10375497 MGI
involved in positive regulation of smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
28867608 MGI
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
10375497 MGI
acts upstream of or within positive regulation of vascular associated smooth muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
16644864 MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
11940581 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: 通过突变表型推断
25224828 MGI
acts upstream of or within retina vasculature development in camera-type eye IMP
IMP: 通过突变表型推断
25224828 MGI
acts upstream of or within substrate-dependent cell migration IDA
IDA: 通过直接分析推断
15183724 MGI
acts upstream of or within synapse assembly IMP
IMP: 通过突变表型推断
25224828 MGI
acts upstream of vascular associated smooth muscle cell migration IGI
IGI: 通过遗传相互作用推断
16644864 MGI
acts upstream of vascular associated smooth muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
16644864 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

platelet-derived growth factor subunit B

PDGF subunit B

platelet-derived growth factor B chain

platelet-derived growth factor beta polypeptide

proto-oncogene c-Sis

重组 Pdgfb 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7087 PDGF-BB Protein, Mouse P31240 (S82-T190) ≥95%
HY-P70699 PDGF-BB Protein, Mouse (His) AAH53430.1 (S82-T190) ≥95%
HY-P73352 PDGF-BB Protein, Mouse (P.pastoris, His) AAH23427.1 (S82-T190) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pdgfb NCBI NCBI:5155
Canis familiaris Pdgfb NCBI NCBI:442986
Macaca fascicularis Pdgfb NCBI NCBI:102125183
Rattus norvegicus Pdgfb NCBI NCBI:24628
Macaca mulatta Pdgfb NCBI NCBI:703173