2. Gene
  3. Pdgfb - platelet derived growth factor subunit B Gene

Pdgfb - platelet derived growth factor subunit B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: SIS; c-sis

基因 ID: 24628 | 基因类型: protein coding

关于 Pdgfb

功能概要

Enables signaling receptor binding activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of cell migration; and response to peptide hormone. Located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Used to study asthma; brain infarction; glomerulonephritis; and visual epilepsy. Biomarker of cholestasis; hypertension (multiple); liver cirrhosis; oligohydramnios; and ureteral obstruction. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue Cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B). [provided by Alliance of Genome Resources, Apr 2022]

Pdgfb 基因产物(2)

mRNA Protein Name
NM_031524.1 NP_113712.1 platelet-derived growth factor subunit B precursor
NM_031524.1 NP_113712.1 platelet-derived growth factor subunit B precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables signaling receptor binding IMP
IMP: 通过突变表型推断
16014047 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to angiotensin IEP
IEP: 通过表达模式推断
10506481 RGD
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
7653578 RGD
involved in cellular response to mycophenolic acid IDA
IDA: 通过直接分析推断
18723570 RGD
involved in male gonad development IEP
IEP: 通过表达模式推断
11870082 RGD
involved in myoblast proliferation IEP
IEP: 通过表达模式推断
2425941 RGD
involved in platelet-derived growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
17449016 RGD
involved in positive regulation of DNA replication IMP
IMP: 通过突变表型推断
12084843 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18723570 RGD
involved in positive regulation of MAP kinase activity IDA
IDA: 通过直接分析推断
19460854 RGD
involved in positive regulation of collagen biosynthetic process IMP
IMP: 通过突变表型推断
15358192 RGD
involved in positive regulation of hepatic stellate cell activation IMP
IMP: 通过突变表型推断
15358192 RGD
involved in positive regulation of hepatic stellate cell proliferation IMP
IMP: 通过突变表型推断
15358192 RGD
involved in positive regulation of metanephric mesenchymal cell migration IDA
IDA: 通过直接分析推断
19460854 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
17449016 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
17449016 RGD
involved in regulation of cell population proliferation IEP
IEP: 通过表达模式推断
7758166 RGD
involved in response to axon injury IEP
IEP: 通过表达模式推断
7922556 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
14724432 RGD
involved in response to estrogen IEP
IEP: 通过表达模式推断
14724432 RGD
involved in response to human chorionic gonadotropin IEP
IEP: 通过表达模式推断
17108335 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
8447423 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
12606528 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
16156274 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
16156274 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
10550325 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
10550325 RGD
located in dendrite IDA
IDA: 通过直接分析推断
14980813 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
9072322 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
7922556 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

platelet-derived growth factor subunit B

PDGF subunit B

PDGF-2

Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis)

pdgf protein

platelet derived growth factor, B polypeptide

platelet derived growth factor-bb

platelet-derived growth factor B chain

p

重组 Pdgfb 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7278 PDGF-BB Protein, Rat Q05028 (S74-T182) ≥95%
HY-P7278A PDGF-BB Protein, Rat (His) Q05028 (S74-T182) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-160047 AX102 sodium / 否
HY-160048 PEG40K unconjugated/naked AX102 sodium / 否
HY-RS10251 PDGFB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pdgfb NCBI NCBI:5155
Canis familiaris Pdgfb NCBI NCBI:442986
Macaca fascicularis Pdgfb NCBI NCBI:102125183
Mus musculus Pdgfb NCBI NCBI:18591
Macaca mulatta Pdgfb NCBI NCBI:703173
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