1. Gene
  2. Pik3c2a - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Gene

Pik3c2a - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Gene

中文名称:磷脂酰肌醇 4-磷酸 3-激酶催化亚基 2 型 α

种属: Mus musculus

同用名: Cpk-m; PI3KC2

基因 ID: 18704 | 基因类型: protein coding

关于 Pik3c2a

Chromosome 7: 115,936,500-116,042,684 reverse strand.GRCm39:CM001000.3

This gene has 7 transcripts (splice variants), 222 orthologues, 9 paralogues and is associated with 72 phenotypes. Ubiquitous expression in placenta adult (RPKM 5.5), limb E14.5 (RPKM 4.) and 25 other tissues.

功能概要

该基因编码的蛋白可启动 1-磷脂酰肌醇-3-激酶活性。作用于多个过程的上游或内部,包括自噬体组织;锌离子跨膜转运的负调节;和磷脂酰肌醇-3-磷酸生物合成过程。预计位于几种细胞成分中,包括网格蛋白包被的囊泡;核质;和跨高尔基网络。预计是磷脂酰肌醇 3-激酶复合物的一部分。预计在细胞质和质膜中有活性。与人 PIK3C2A(磷脂酰肌醇 4-磷酸 3-激酶催化亚基 2 型 α)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables 1-phosphatidylinositol-3-kinase activity. Acts upstream of or within several processes, including autophagosome organization; negative regulation of zinc ion transmembrane transport; and phosphatidylinositol-3-phosphate biosynthetic process. Predicted to be located in several cellular components, including clathrin-coated vesicle; nucleoplasm; and trans-Golgi network. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c2a 基因产物(1)

mRNA Protein Name
NM_011083.2 NP_035213.2 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-phosphatidylinositol-3-kinase activity IDA
IDA: 通过直接分析推断
8663140 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within autophagosome organization IGI
IGI: 通过遗传相互作用推断
24098492 MGI
acts upstream of or within cellular response to starvation IGI
IGI: 通过遗传相互作用推断
24098492 MGI
acts upstream of or within macroautophagy IGI
IGI: 通过遗传相互作用推断
24098492 MGI
acts upstream of or within negative regulation of zinc ion transmembrane transport IMP
IMP: 通过突变表型推断
23823722 MGI
acts upstream of or within phosphatidylinositol-3-phosphate biosynthetic process IGI
IGI: 通过遗传相互作用推断
24098492 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Pik3c2a 蛋白结构

PI3K_rbd

PI3K_rbd: pfam00794 (419 - 512)

C2A_PI3K_class_II

C2A_PI3K_class_II: cd04012 (676 - 848)

PI3Ka_II

PI3Ka_II: cd00869 (868 - 1037)

PI3Kc_C2_alpha

PI3Kc_C2_alpha: cd05176 (1042 - 1394)

PX_PI3K_C2_alpha

PX_PI3K_C2_alpha: cd07289 (1425 - 1533)

C2B_PI3K_class_II

C2B_PI3K_class_II: cd08381 (1559 - 1680)

  • 0
  • 300
  • 600
  • 900
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  • 1500
  • 1686 a.a.
蛋白主名 其他名称

phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

PI3K-C2-alpha

p170

phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide

phosphoinositide 3-kinase-C2-alpha

ptdIns-3-kinase C2 subunit alpha

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pik3c2a NCBI NCBI:5286