Prkch - protein kinase C, eta Gene

中文名称：蛋白激酶 C, eta

种属: Mus musculus

同用名: Pkch

关于 Prkch

功能概要

蛋白激酶 C (PKC) 是一个丝氨酸和苏氨酸特异性蛋白激酶家族，可被钙和第二信使甘油二酯激活。 PKC 家族成员磷酸化多种蛋白质靶标，并且已知参与多种细胞信号通路。 PKC 家族成员还充当佛波酯（一类肿瘤促进剂）的主要受体。 PKC 家族的每个成员都有特定的表达谱，并被认为在细胞中发挥着独特的作用。该基因编码的蛋白质是 PKC 家族成员之一。它是一种钙非依赖性和磷脂依赖性蛋白激酶。它主要在上皮组织中表达，并已显示特异性存在于细胞核中。这种蛋白激酶可以通过激活 MAP 激酶 MAPK13 (p38delta) 激活的蛋白激酶级联来调节角质形成细胞分化，该级联靶向 CCAAT/增强子结合蛋白 alpha (CEBPA)。它还被发现介导转谷氨酰胺酶 1 (TGM1) 基因的转录激活。人类基因的突变与脑梗塞的易感性有关。可变剪接导致编码不同异构体的多个转录变体。 [RefSeq 提供，2015 年 9 月]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in the human gene are associated with susceptibility to cerebral infarction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]