E4F1 - E4F transcription factor 1 Gene

中文名称：E4F 转录因子 1

种属: Homo sapiens

同用名: E4F

关于 E4F1

功能概要

由该基因编码的锌指蛋白是几种细胞转录因子之一，其 DNA 结合活性通过腺病毒 E1A 的作用进行调节。通过蛋白水解切割，从全长蛋白质生成 50-kDa 氨基末端产物。该蛋白质受 E1A 诱导的磷酸化的差异调节。在没有 E1A 的情况下，全长基因产物抑制 E4 启动子的转录，而 50-kDa 形式在其存在时充当转录激活因子。可变剪接导致编码不同蛋白质的多个转录本。[RefSeq 提供，2014 年 1 月]

The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]