2. Gene
  3. EBF1 - EBF transcription factor 1 Gene

EBF1 - EBF transcription factor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：EBF 转录因子 1

种属: Homo sapiens

同用名: EBF; COE1; OLF1; O/E-1

基因 ID: 1879 | 基因类型: protein coding

关于 EBF1

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:158,695,920-159,099,916 (from NCBI)

This gene has 11 transcripts (splice variants), 300 orthologues, 3 paralogues and is associated with 83 phenotypes. Broad expression in fat (RPKM 3.2), placenta (RPKM 0.8) and 17 other tissues.

功能概要

预测可实现 DNA 结合转录激活因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。预测参与 RNA 聚合酶 II 对转录的正调控。预测作用于转录正调控的上游或正调控内，DNA 模板化。预测位于核内。预测是染色质的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

EBF1 基因产物(15)

mRNA Protein Name
NM_001290360.3 NP_001277289.1 transcription factor COE1 isoform 1
NM_001324101.2 NP_001311030.1 transcription factor COE1 isoform 4
NM_001324103.2 NP_001311032.1 transcription factor COE1 isoform 5
NM_001324106.2 NP_001311035.1 transcription factor COE1 isoform 6
NM_001324107.2 NP_001311036.1 transcription factor COE1 isoform 7
NM_001324108.2 NP_001311037.1 transcription factor COE1 isoform 8
NM_001324109.2 NP_001311038.1 transcription factor COE1 isoform 9
NM_001324111.2 NP_001311040.1 transcription factor COE1 isoform 10
NM_001364155.2 NP_001351084.1 transcription factor COE1 isoform 11
NM_001364156.2 NP_001351085.1 transcription factor COE1 isoform 13
NM_001364157.2 NP_001351086.1 transcription factor COE1 isoform 14
NM_001364158.2 NP_001351087.1 transcription factor COE1 isoform 15
NM_001364159.2 NP_001351088.1 transcription factor COE1 isoform 16
NM_024007.5 NP_076870.1 transcription factor COE1 isoform 2
NM_182708.3 NP_874367.1 transcription factor COE1 isoform 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EBF1 蛋白结构

TIG

TIG: IPT/TIG domain (262 - 344)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 591 a.a.
蛋白主名 其他名称

transcription factor COE1

Collier, Olf and EBF transcription factor 1

EBF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EBF1 Q9UH73 HOMEZ Homo sapiens Q8IX15-3
Validated Y2H
25416956
种属内
EBF1 Q9UH73 HOMEZ Homo sapiens Q8IX15-3
Y2H Prey Pooling
25416956
种属内
EBF1 Q9UH73 HOMEZ Homo sapiens Q8IX15-3
Y2H Array
25416956
种属内
EBF1 Q9UH73 ATPAF2 Homo sapiens Q8N5M1
Y2H Array
25416956
种属内
EBF1 Q9UH73 ATPAF2 Homo sapiens Q8N5M1
MAPPIT
32296183
种属内
EBF1 Q9UH73 ATPAF2 Homo sapiens Q8N5M1
Y2H Array
32296183
种属内
EBF1 Q9UH73 ATPAF2 Homo sapiens Q8N5M1
Y2H Prey Pooling
32296183
种属内
EBF1 Q9UH73 POU6F2 Homo sapiens P78424
Y2H Array
32296183
种属内
EBF1 Q9UH73 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
种属内
EBF1 Q9UH73 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
种属内
EBF1 Q9UH73 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属内
EBF1 Q9UH73 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

EBF1 抗体

目录号 产品名 应用 反应物种
HY-P82193 EBF1 Antibody (YA1938) WB Human, Mouse

关联疾病

疾病名称 别名
Plasmacytoma

Solitary Plasmacytoma

Solitary Myeloma

Myeloma - Solitary

Myeloma, Solitary

Plasmacytoma - Category

Solitary Osseous Plasmacytoma

Solitary Plasmacytoma Without Mention Of Remission

Localised Malignant Plasma Cell Tumour Nos

Plasmacytoma Nos
Breast Abscess

Abscess Of Breast
B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1

B-All With Bcr-Abl1

B-Lymphoblastic Leukemia/Lymphoma With T(9

22)(Q34.1

Q11.2)

Bcr-Abl1

B Lymphoblastic Leukemia/Lymphoma With T(9

22)(Q34.1

Q11.2)

Bcr-Abl1
Postpartum Depression

Maternity Blues

Postnatal Depression

Depression, Postpartum

Post-Partum Depression

Depression Postpartum
B-Lymphoblastic Leukemia/Lymphoma With Iamp21

B-All With Iamp21

Intrachromosomal Amplification Of Chromosome 21
Endogenous Depression

Clinical Depression

Unipolar Depression

Depressive Disorder
Tetanus Neonatorum

Neonatal Tetanus

NNT

Trismus Neonatorum

Newborn Trismus
Prion Disease

Spongiform Encephalopathy

Transmissible Spongiform Encephalopathies

Prion Diseases

Prion Disease Pathway

Transmissible Spongiform Encephalopathy

Prion Induced Disorder

Prion Protein Disease

Inherited Human Transmissible Spongiform Encephalopathies

Prion Protein Diseases

Prion-Associated Disorders

Prion-Induced Disorders

Transmissible Dementias

Tses

Human Prion Disease

Tse

Encephalopathy, Transmissible Spongiform

Prion Disease, Susceptibility To

Spongiform Encephalopathies

Human Transmissible Spongiform Encephalopathies, Inherited
B-Lymphoblastic Leukemia/Lymphoma

B Lymphoblastic Leukemia/Lymphoma

B-All

Precursor B Lymphoblastic Lymphoma/Leukemia

C-All

Lymphoblastic Lymphoma, Nos

Common Precursor B All

Lymphoblastic B-Cell Lymphoma

Pro-B All

B-Precursor Lymphoma

Lbl - [Lymphoblastic Lymphoma]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04124 EBF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus EBF1 VGNC VGNC:50162
Macaca mulatta EBF1 VGNC VGNC:72030
Mus musculus EBF1 MGD MGI:95275
Rattus norvegicus EBF1 RGD RGD:620953
Felis catus EBF1 VGNC VGNC:61703
Canis familiaris EBF1 VGNC VGNC:40175
Others EBF1 NCBI
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