2. Gene
  3. GPR183 - G protein-coupled receptor 183 Gene

GPR183 - G protein-coupled receptor 183 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 183

种属: Homo sapiens

同用名: EBI2; hEBI2

基因 ID: 1880 | 基因类型: protein coding

关于 GPR183

Cytogenetic location: 13q32.3 Genomic coordinates (GRCh38): 13:99,294,539-99,307,399 (from NCBI)

This gene has 1 transcript (splice variant), 207 orthologues and 7 paralogues. Broad expression in appendix (RPKM 44.7), bone marrow (RPKM 34.8) and 17 other tissues.

功能概要

该基因是通过其在原代 B 淋巴细胞的 Epstein-Barr 病毒感染后的表达上调来鉴定的。预计该基因编码与凝血酶受体关系最密切的 G 蛋白偶联受体。在 B 淋巴细胞系和淋巴组织中检测到该基因的表达，但在 T 淋巴细胞系或外周血 T 淋巴细胞中未检测到。该基因的功能未知。[RefSeq 提供，2008 年 7 月]

This gene was identified by the up-regulation of its expression upon Epstein-Barr virus Infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the Thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]

GPR183 基因产物(1)

mRNA Protein Name
NM_004951.5 NP_004942.1 G-protein coupled receptor 183
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IDA
IDA: 通过直接分析推断
18628402 GOA
enables oxysterol binding IDA
IDA: 通过直接分析推断
21796212 GOA
enables oxysterol binding IMP
IMP: 通过突变表型推断
24678947 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
18628402 GOA
involved in leukocyte chemotaxis IMP
IMP: 通过突变表型推断
24678947 GOA
involved in positive regulation of B cell proliferation IDA
IDA: 通过直接分析推断
21673108 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
21673108 GOA
involved in regulation of astrocyte chemotaxis IDA
IDA: 通过直接分析推断
25297897 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
18628402 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPR183 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (48 - 308)

  • 0
  • 100
  • 200
  • 300
  • 361 a.a.
蛋白主名 其他名称

G-protein coupled receptor 183

EBV-induced G-protein coupled receptor 2

Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)

epstein-Barr virus-induced G-protein coupled receptor 2

关联疾病

疾病名称 别名
Bile Acid Synthesis Defect, Congenital, 3

Congenital Bile Acid Synthesis Defect 3

CBAS3

Oxysterol 7-Alpha-Hydroxylase Deficiency

Congenital Bile Acid Synthesis Defect Type 3

Basd3

Bile Acid Synthesis Defect, Congenital, Type 3
Congenital Bile Acid Synthesis Defect

3-Beta-Hydroxy-Delta-5-C27-Steroid Oxidoreductase Deficiency

Cba

Cholestasis With Delta(4)-3-Oxosteroid-5-Beta-Reductase Deficiency

Basd

Bile Acid Synthesis Defect, Congenital, 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-113962 7α,25-Dihydroxycholesterol Agonist ≥99.0% 否
HY-162011 GPR183 antagonist-2 Antagonist 99.96% 否
HY-147222 SAE-14 Antagonist 98.26% 否
HY-113962S 7α,25-Dihydroxycholesterol-d6 / 否
HY-162618 PSB-KK1445 Agonist 99.47% 否
HY-163796 GPR183-IN-2 Inhibitor 99.90% 否
HY-157939 GPR183 antagonist-3 Antagonist / 否
HY-163795 GPR183-IN-1 Inhibitor / 否
HY-RS05690 GPR183 Human Pre-designed siRNA Set A / 否
HY-RS05691 Gpr183 Mouse Pre-designed siRNA Set A / 否
HY-RS05692 Gpr183 Rat Pre-designed siRNA Set A / 否
HY-400897 7α,25-Dihydroxycholesterol intermediate-1 / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GPR183 VGNC VGNC:73042
Rattus norvegicus GPR183 RGD RGD:1598095
Mus musculus GPR183 MGD MGI:2442034
Canis familiaris GPR183 VGNC VGNC:41423
Bos taurus GPR183 VGNC VGNC:29577
Others GPR183 NCBI
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