2. Gene
  3. Mtnr1b - melatonin receptor 1B Gene

Mtnr1b - melatonin receptor 1B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：褪黑激素受体 1B

种属: Rattus norvegicus

同用名: Mt2; Mel1b-r

基因 ID: 192646 | 基因类型: protein coding

关于 Mtnr1b

Primary_assembly 8: 12,638,219-12,652,737 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 106 orthologues, 50 paralogues and is associated with 5 phenotypes. Low expression observed in reference dataset.

功能概要

预计该基因编码的蛋白可启动 G 蛋白偶联受体活性。参与多个过程，包括 cGMP 介导的信号传导的负调节；运输的负面监管；和调节神经冲动的传递。预计是膜的组成部分。预计在质膜上有活性。用于研究急性胰腺炎。该基因的人类直系同源物与 2 型糖尿病有关。与人类 MTNR1B（褪黑激素受体 1B）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable G protein-coupled receptor activity. Involved in several processes, including negative regulation of cGMP-mediated signaling; negative regulation of transport; and regulation of transmission of nerve impulse. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Used to study acute pancreatitis. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MTNR1B (Melatonin Receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]

Mtnr1b 基因产物(1)

mRNA Protein Name
NM_001393841.1 NP_001380770.1 melatonin receptor type 1B precursor
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in camera-type eye development IEP
IEP: 通过表达模式推断
12890503 RGD
involved in negative regulation of cGMP-mediated signaling IMP
IMP: 通过突变表型推断
18363673 RGD
involved in negative regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
14675130 RGD
involved in negative regulation of delayed rectifier potassium channel activity IDA
IDA: 通过直接分析推断
14962062 RGD
involved in negative regulation of insulin secretion IMP
IMP: 通过突变表型推断
18363673 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
14962062 RGD
involved in negative regulation of transmission of nerve impulse IMP
IMP: 通过突变表型推断
15082174 RGD
involved in negative regulation of vasoconstriction IMP
IMP: 通过突变表型推断
10199853 RGD
involved in positive regulation of circadian rhythm IDA
IDA: 通过直接分析推断
12643943 RGD
involved in positive regulation of circadian sleep/wake cycle, non-REM sleep IDA
IDA: 通过直接分析推断
19429170 RGD
involved in positive regulation of circadian sleep/wake cycle, non-REM sleep IMP
IMP: 通过突变表型推断
22171046 RGD
involved in positive regulation of transmission of nerve impulse IDA
IDA: 通过直接分析推断
22171046 RGD
involved in regulation of neuronal action potential IMP
IMP: 通过突变表型推断
21094224 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mtnr1b 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (40 - 318)

7tm_GPCRs

7tm_GPCRs: cd14964 (42 - 66)

7tm_GPCRs

7tm_GPCRs: cd14964 (75 - 97)

7tm_GPCRs

7tm_GPCRs: cd14964 (113 - 135)

7tm_GPCRs

7tm_GPCRs: cd14964 (158 - 174)

7tm_GPCRs

7tm_GPCRs: cd14964 (197 - 220)

7tm_GPCRs

7tm_GPCRs: cd14964 (249 - 271)

7tm_GPCRs

7tm_GPCRs: cd14964 (286 - 311)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
蛋白主名 其他名称

melatonin receptor type 1B

mel-1B-R

mel1b melatonin receptor

mel1b receptor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08807 Mtnr1b Mouse Pre-designed siRNA Set A / 否
HY-RS08806 MTNR1B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08808 Mtnr1b Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mtnr1b NCBI NCBI:4544
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