2. Gene
  3. EFNB3 - ephrin B3 Gene

EFNB3 - ephrin B3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肝配蛋白 B3

种属: Homo sapiens

同用名: EFL6; EPLG8; LERK8

基因 ID: 1949 | 基因类型: protein coding

关于 EFNB3

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,705,202-7,711,372 (from NCBI)

This gene has 1 transcript (splice variant), 230 orthologues and 7 paralogues. Biased expression in brain (RPKM 19.7), endometrium (RPKM 6.5) and 5 other tissues.

功能概要

EFNB3 是 ephrin 基因家族的一员，在大脑发育和维持方面都很重要。此外，由于与其他脑子区域相比，几个前脑子区域的 EFNB3 表达水平特别高，因此它可能在前脑功能中发挥关键作用。 EPH 和 EPH 相关受体包含受体蛋白-酪氨酸激酶的最大亚家族，并且与介导发育事件有关，特别是在神经系统中。 EPH 受体通常有一个激酶结构域和一个含有富含半胱氨酸结构域和 2 个纤连蛋白 III 型重复序列的胞外区。肝配蛋白配体和受体已由 Eph 命名委员会 (1997) 命名。基于它们的结构和序列关系，肝配蛋白分为肝配蛋白-A (EFNA) 类和肝配蛋白 B (EFNB) 类，前者通过糖基磷脂酰肌醇键固定在膜上，后者是跨膜蛋白。基于其细胞外结构域序列的相似性和它们对结合肝配蛋白-A 和肝配蛋白-B 配体的亲和力，Eph 受体家族同样分为 2 组。[RefSeq 提供，2008 年 7 月]

EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to Other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Eph Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

EFNB3 基因产物(1)

mRNA Protein Name
NM_001406.4 NP_001397.1 ephrin-B3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ephrin receptor binding IDA
IDA: 通过直接分析推断
8808709 GOA
enables ephrin receptor binding IPI
IPI: 通过物理相互作用推断
11519828 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23812375 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within ephrin receptor signaling pathway IDA
IDA: 通过直接分析推断
8808709 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
17251577 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EFNB3 蛋白结构

Ephrin

Ephrin: Ephrin (29 - 169)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
蛋白主名 其他名称

ephrin-B3

EPH-related receptor transmembrane ligand ELK-L3

EFNB3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EFNB3 Q15768 EPHA4 Homo sapiens P54764
Anti Tag CoIP
33961781
种属内
EFNB3 Q15768 EPHA4 Homo sapiens P54764
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nipah Virus Encephalitis

Equine Morbillivirus
Craniofrontonasal Syndrome

Craniofrontonasal Dysplasia

CFNS

Cfnd

Craniofrontonasal Dysostosis

Craniofrontonasal Dystosis

Dysplasia, Craniofrontonasal
Anterior Segment Dysgenesis 5

Anterior Segment Dysgenesis 5, Multiple Subtypes

ASGD5

Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04199 EFNB3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris EFNB3 VGNC VGNC:40230
Mus musculus EFNB3 MGD MGI:109196
Rattus norvegicus EFNB3 RGD RGD:2541
Bos taurus EFNB3 VGNC VGNC:28361
Felis catus EFNB3 VGNC VGNC:98946
Macaca mulatta EFNB3 VGNC VGNC:104599
Others EFNB3 NCBI
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