2. Gene
  3. EIF4B - eukaryotic translation initiation factor 4B Gene

EIF4B - eukaryotic translation initiation factor 4B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：真核翻译起始因子 4B

种属: Homo sapiens

同用名: EIF-4B; PRO1843

基因 ID: 1975 | 基因类型: protein coding

关于 EIF4B

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,006,456-53,042,215 (from NCBI)

This gene has 14 transcripts (splice variants), 262 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 285.6), thyroid (RPKM 146.6) and 25 other tissues.

功能概要

启用 RNA 结合活性。预计参与真核翻译起始因子 4F 复合物的组装和翻译预起始复合物的形成。位于胞质溶胶中。自闭症谱系障碍和重度抑郁症的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Located in cytosol. Biomarker of autism spectrum disorder and major depressive disorder. [provided by Alliance of Genome Resources, Apr 2022]

EIF4B 基因产物(3)

mRNA Protein Name
NM_001300821.3 NP_001287750.1 eukaryotic translation initiation factor 4B isoform 1
NM_001330654.2 NP_001317583.1 eukaryotic translation initiation factor 4B isoform 3
NM_001417.7 NP_001408.2 eukaryotic translation initiation factor 4B isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21044950 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EIF4B 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (99 - 167)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 611 a.a.
蛋白主名 其他名称

eukaryotic translation initiation factor 4B

EIF4B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EIF4B P23588 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
种属内
EIF4B P23588 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
种属内
EIF4B P23588 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
种属内
EIF4B P23588 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
种属内
EIF4B P23588 KLK6 Homo sapiens Q92876
Y2H Array
32814053
种属内
EIF4B P23588 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
种属内
EIF4B P23588 PLK1 Homo sapiens P53350
Protein Kinase Assay
21887822
种属内
EIF4B P23588 TINF2 Homo sapiens Q9BSI4
Pull Down
21044950
种属间: 跨种属相互作用 种属内: 同种属相互作用

EIF4B 抗体

目录号 产品名 应用 反应物种
HY-P80651 eIF4B Antibody WB, IHC-P Human

关联疾病

疾病名称 别名
Mouth Disease

Mouth Diseases

Mouth Disorders
Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-129239 Farudodstat 99.68% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04273 EIF4B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus EIF4B RGD RGD:1306479
Mus musculus EIF4B MGD MGI:95304
Canis familiaris EIF4B VGNC VGNC:40282
Bos taurus EIF4B VGNC VGNC:28407
Felis catus EIF4B VGNC VGNC:61790
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